Topoisomerase

Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I… (More)
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Topoisomerases are complex molecular machines that modulate DNA topology to maintain chromosome superstructure and integrity… (More)
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Highly Cited
2011
Highly Cited
2011
The ribonuclease (RNase) H class of enzymes degrades the RNA component of RNA:DNA hybrids and is important in nucleic acid… (More)
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Highly Cited
2009
Highly Cited
2009
Topoisomerases regulate DNA topology and are fundamental to many aspects of chromosome metabolism. Their activity involves the… (More)
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Highly Cited
2008
Highly Cited
2008
RanBP2 is a nucleoporin with SUMO E3 ligase activity that functions in both nucleocytoplasmic transport and mitosis. However, the… (More)
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Highly Cited
2007
Highly Cited
2007
Doxorubicin is among the most effective and widely used anticancer drugs in the clinic. However, cardiotoxicity is one of the… (More)
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Highly Cited
2006
Highly Cited
2006
Bloom syndrome (BS), an autosomal recessive disorder, is marked by a high incidence of cancer early in life. Cells derived from… (More)
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Highly Cited
2002
Highly Cited
2002
Endoreduplication is a common process in eukaryotes that involves DNA amplification without corresponding cell divisions. Cell… (More)
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Highly Cited
2000
Highly Cited
2000
DNA topoisomerase IIbeta is shown to have an unsuspected and critical role in neural development. Neurogenesis was normal in… (More)
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Highly Cited
1996
Highly Cited
1996
Camptothecin is an S-phase-specific anticancer agent that inhibits the activity of the enzyme DNA topoisomerase-I (topo-I… (More)
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Highly Cited
1994
Highly Cited
1994
We have previously shown that cells mutant for TOP3, a gene encoding a prokaryotic-like type I topoisomerase in Saccharomyces… (More)
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