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Topoisomerase
Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I…
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National Institutes of Health
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Related topics
Related topics
5 relations
DNA Replication
DNA Topoisomerase IV
Enzyme Gene
Transcription, Genetic
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents.
A. Kamal
,
B. A. Kumar
,
P. Suresh
,
A. Juvekar
,
S. Zingde
Bioorganic & Medicinal Chemistry
2011
Corpus ID: 31760651
1997
1997
The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase IIα*
T. Hammonds
,
A. Maxwell
Journal of Biological Chemistry
1997
Corpus ID: 29279842
We have purified human topoisomerase IIα from HeLa cells and studied its ATPase reaction. The ATPase activity is stimulated by…
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1996
1996
Bacteriophage T4 mutants hypersensitive to an antitumor agent that induces topoisomerase-DNA cleavage complexes.
D. L. Woodworth
,
K. Kreuzer
Genetics
1996
Corpus ID: 18587525
Many antitumor agents and antibiotics affect cells by interacting with type II topoisomerases, stabilizing a covalent enzyme-DNA…
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Highly Cited
1994
Highly Cited
1994
Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions.
J. Stivers
,
S. Shuman
,
A. Mildvan
Biochemistry
1994
Corpus ID: 9082168
Vaccinia DNA topoisomerase I catalyzes a reversible, site-specific strand cleavage and resealing reaction with duplex DNA…
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Highly Cited
1989
Highly Cited
1989
Drug-promoted cleavage of kinetoplast DNA minicircles. Evidence for type II topoisomerase activity in trypanosome mitochondria.
T. Shapiro
,
V. Klein
,
P. T. Englund
Journal of Biological Chemistry
1989
Corpus ID: 37496345
Minicircle DNA, the major component of the mitochondrial DNA of trypanosomes (kinetoplast DNA), is linearized when living…
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Highly Cited
1986
Highly Cited
1986
DNA breakage in human lung carcinoma cells and nuclei that are naturally sensitive or resistant to etoposide and teniposide.
B. Long
,
S. Musial
,
M. Brattain
Cancer Research
1986
Corpus ID: 578016
1986
1986
Bacteriophage T4 DNA topoisomerase mediates illegitimate recombination in vitro.
H. Ikeda
Proceedings of the National Academy of Sciences…
1986
Corpus ID: 19925167
We have found that purified T4 DNA topoisomerase promotes recombination between two phage lambda DNA molecules in an in vitro…
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Highly Cited
1983
Highly Cited
1983
Reversible decatenation of kinetoplast DNA by a DNA topoisomerase from trypanosomatids.
J. Shlomai
,
A. Zadok
Nucleic Acids Research
1983
Corpus ID: 10978809
DNA topoisomerase activity detected in cell extracts of the trypanosomatid Crithidia fasciculata interlocks kinetoplast DNA…
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1980
1980
Analysis of covalent complexes formed between calf thymus DNA topoisomerase and single-stranded DNA.
B. Prell
,
H. Vosberg
European Journal of Biochemistry
1980
Corpus ID: 2048515
DNA topoisomerases (or nicking-closing enzymes) introduce transient swivels into DNA. We studied the reaction of the calf thymus…
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1979
1979
Mitochondria contain a distinct DNA topoisomerase.
F. Fairfield
,
W. Bauer
,
M. Simpson
Journal of Biological Chemistry
1979
Corpus ID: 24247436
A topoisomerase (nicking-closing enzyme) has been isolated from rat liver mitochondria. It has purified by double-stranded DNA…
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