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Topoisomerase
Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I…
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National Institutes of Health
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Related topics
Related topics
5 relations
DNA Replication
DNA Topoisomerase IV
Enzyme Gene
Transcription, Genetic
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Induction of Apoptosis of Human Tumor Cells by a 4,9-Diazapyrenium Derivative and Its Affects on Topoisomerase-II Action
Saška Marczi
,
L. Glavaš‐Obrovac
,
I. Karner
Chemotherapy
2005
Corpus ID: 24685129
Background: 5,10-Diphenyl-4,9-dimethyl-4,9-diazapyrenium hydrogensulfate (FDAP) is a newly synthesized DNA intercalator with…
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2001
2001
[Interaction of topotecan--a DNA topoisomerase inhibitor--with dual-stranded polydeoxyribonucleotides. I. Dimerization of topotecan in solution].
S. Strel’tsov
,
S. L. Grokhovskii
,
I. Kudelina
,
V. Oleinikov
,
A. Zhuze
Молекулярная биология
2001
Corpus ID: 35574424
Behavior of topotecan, DNA topoisomerase I inhibitor, was studied in aqueous solutions by optical methods. Topotecan absorption…
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1999
1999
Protein–nucleotide interactions in E. coli DNA topoisomerase I
H. Feinberg
,
A. Changela
,
A. Mondragón
Nature Structural Biology
1999
Corpus ID: 20620322
DNA topoisomerases are the enzymes responsible for controlling and maintaining the topological states of DNA. Type IA enzymes…
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1990
1990
Relationships among tumor responsiveness, cell sensitivity, doxorubicin cellular pharmacokinetics and drug‐induced DNA alterations in two human small‐cell lung cancer xenografts
G. Pratesi
,
G. Capranico
,
+4 authors
F. Zunino
International Journal of Cancer
1990
Corpus ID: 41141805
In an attempt to understand the underlying cellular/biochemical factors of sensitivity/resistance in human small‐cell lung cancer…
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1986
1986
Bacteriophage T4 DNA topoisomerase mediates illegitimate recombination in vitro.
H. Ikeda
Proceedings of the National Academy of Sciences…
1986
Corpus ID: 19925167
We have found that purified T4 DNA topoisomerase promotes recombination between two phage lambda DNA molecules in an in vitro…
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1986
1986
Potentiation of sister chromatid exchange by 3-aminobenzamide is not modulated by topoisomerases or proteases.
W. Morgan
,
Y. Doida
,
M. Fero
,
X. C. Guo
,
J. Shadley
Environmental Mutagenesis
1986
Corpus ID: 22680018
Poly(ADP-ribose) is synthesized in response to DNA strand breaks and covalently modifies numerous intracellular proteins. We have…
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1985
1985
Simian virus 40 minichromosomes contain torsionally strained DNA molecules
J. Barsoum
,
P. Berg
Molecular and Cellular Biology
1985
Corpus ID: 29364398
Sundin and Varshavsky (J. Mol. Biol. 132:535-546, 1979) found that nearly two-thirds of simian virus 40 (SV40) minichromosomes…
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Highly Cited
1983
Highly Cited
1983
Reversible decatenation of kinetoplast DNA by a DNA topoisomerase from trypanosomatids.
J. Shlomai
,
A. Zadok
Nucleic Acids Research
1983
Corpus ID: 10978809
DNA topoisomerase activity detected in cell extracts of the trypanosomatid Crithidia fasciculata interlocks kinetoplast DNA…
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1981
1981
Regulation of Expression of Cloned Bacteriophage T4 Late Gene 23
K. Jacobs
,
E. Geiduschek
Journal of Virology
1981
Corpus ID: 43094921
The parameters governing the activity of the cloned T4 gene 23, which codes for the major T4 head protein, were analyzed…
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1980
1980
Analysis of covalent complexes formed between calf thymus DNA topoisomerase and single-stranded DNA.
B. Prell
,
H. Vosberg
European Journal of Biochemistry
1980
Corpus ID: 2048515
DNA topoisomerases (or nicking-closing enzymes) introduce transient swivels into DNA. We studied the reaction of the calf thymus…
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