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A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells.
Covalently closed circular duplex DNA’s are now known to be widespread among living organisms. This DNA structure, originally identified in polyoma viral DNA,1’2 has been assigned to theExpand
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Binding of cis- and trans-dichlorodiammineplatinum(II) to DNA: evidence for unwinding and shortening of the double helix.
The antitumor drug cis-dichlorodiammineplatinum(II) (cis-DDP) and the inactive trans isomer bind and produce cooperative changes in closed and nicked circular duplex DNA's. Covalent binding of bothExpand
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Structure and reactions of closed duplex DNA.
  • W. Bauer
  • Chemistry, Medicine
  • Annual review of biophysics and bioengineering
  • 1978
Closed duplex (cd) DNA was first detected in 1963 in extracts of polyoma virus (49, 149), and the unique structural properties of this nucleic acid were recognized in 1965 by Vinograd and co-workersExpand
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Metallointercalation reagents. 2-hydroxyethanethiolato(2,2',2'-terpyridine)-platinum(II) monocation binds strongly to DNA by intercalation.
The red, cationic complex 2-hydroxy-ethanethiolato(2,2',2''-terpyridine)platinum(II), [(terpy)-Pt(SCH(2)CH(2)OH)](+), binds strongly to DNA by a mechanism involving intercalation. By means ofExpand
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The interaction of closed circular DNA with intercalative dyes. I. The superhelix density of SV40 DNA in the presence and absence of dye.
Abstract The binding of the intercalating dye ethidium bromide to closed circular SV40 DNA causes an unwinding of the duplex structure and a simultaneous and quantitatively equivalent unwinding ofExpand
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Interaction of closed circular DNA with intercalative dyes. II. The free energy of superhelix formation in SV40 DNA.
Abstract In part I of this series of papers, the binding isotherms of ethidium bromide to closed circular and nicked circular SV40 DNA were determined. It is shown in the present paper that theExpand
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Supercoiling in closed circular DNA: dependence upon ion type and concentration.
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Binding of platinum and palladium metallointercalation reagents and antitumor drugs to closed and open DNAs.
The interaction of platinum and palladium complexes with closed and nicked circular and linear DNAs was investigated by a variety of methods. Cationic metal complexes containing flat, aromaticExpand
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A DNA nicking-closing enzyme encapsidated in vaccinia virus: partial purification and properties.
Vaccinia virus cores contain an activity which is able to relax both left-and right-handed superhelical DNA. This virus-specific nicking closing enzyme has been highly purified and differs from theExpand
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Nucleosome structural changes due to acetylation.
We have measured the helical repeat of acetylated nucleosomes reconstituted with HeLa cell histone octamers and the 5 S RNA gene positioning sequence from Xenopus borealis. The hydroxyl radicalExpand
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