DNA Topoisomerase IV

Known as: Topoisomerase IV, DNA, Topo IV, DNA Topoisomerase IV [Chemical/Ingredient] 
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Most bacteria possess two type IIA topoisomerases, DNA gyrase and topo IV, that together help manage chromosome integrity and… (More)
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Highly Cited
2000
Highly Cited
2000
DNA supercoiling is essential for bacterial cell survival. We demonstrated that DNA topoisomerase IV, acting in concert with… (More)
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Highly Cited
2000
Highly Cited
2000
We show that positively supercoiled [(+) SC] DNA is the preferred substrate for Escherichia coli topoisomerase IV (topo IV). We… (More)
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Highly Cited
1998
Highly Cited
1998
We examined the response of Streptococcus pneumoniae 7785 to clinafloxacin, a novel C-8-substituted fluoroquinolone which is… (More)
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Review
1997
Review
1997
For many years, DNA gyrase was thought to be responsible both for unlinking replicated daughter chromosomes and for controlling… (More)
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Highly Cited
1996
Highly Cited
1996
Ciprofloxacin-resistant mutants of Streptococcus pneumoniae 7785 were generated by stepwise selection at increasing drug… (More)
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Highly Cited
1996
Highly Cited
1996
DNA gyrase, the bacterial enzyme that supercoils DNA, is trapped on chromosomal DNA by the 4-quinolone compounds, as drug-gyrase… (More)
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Highly Cited
1995
Highly Cited
1995
We have demonstrated that, in Escherichia coli, quinolone antimicrobial agents target topoisomerase IV (topo IV). The inhibition… (More)
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Highly Cited
1995
Highly Cited
1995
For a cell to complete DNA replication, every link between the Watson-Crick strands must be removed by topoisomerases. Previously… (More)
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Highly Cited
1994
Highly Cited
1994
A 4.6 kb Staphylococcus aureus DNA fragment containing DNA gyrase-like genes (grlA and grlB) was cloned and sequenced. The… (More)
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