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Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… 
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (11)

4'-hydroxytolbutamideArtosinDiabetolDiaval

Broader (3)

AntidiabeticsHypoglycemic AgentsSulfonylurea Compounds
Diabetes Mellitus, Non-Insulin-DependentIn BloodPregnancyTolbutamide sodium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Clinical Consequences of Cytochrome P450 2C9 Polymorphisms
Highly Cited
2005
Highly Cited
2005
Hypoglycemic effects of Murraya koenigii on normal and alloxan-diabetic rabbits.
Highly Cited
1998
Highly Cited
1998
Nongenetic mouse models of non-insulin-dependent diabetes mellitus.
Highly Cited
1996
Highly Cited
1996
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.
Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for… 
Highly Cited
1996
Highly Cited
1996
Individual Sulfonylureas and Serious Hypoglycemia in Older People
OBJECTIVE: To compare the risk of serious hypoglycemia associated with the use of individual sulfonylureas in older people. 
Highly Cited
1993
Highly Cited
1993
Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver.
Review
1993
Review
1993
The pharmacology of ATP-sensitive potassium channels.
A potassium (K) channel that was inhibited by physiological (f1M) concen­ trations of intracellular ATP ([ATP]i) and that opened… 
Highly Cited
1992
Highly Cited
1992
Influence of membrane potential changes on cytoplasmic Ca2+ concentration in an electrically excitable cell, the insulin-secreting pancreatic B-cell.
Review
1992
Review
1992
Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes.
Highly Cited
1985
Highly Cited
1985
THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL
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