Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… (More)

Topic mentions per year

Topic mentions per year

1955-2018
05010019552017

Papers overview

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Highly Cited
2006
Highly Cited
2006
BACKGROUND Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin… (More)
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Highly Cited
2004
Highly Cited
2004
Rat insulinoma-derived INS-1 cells constitute a widely used beta-cell surrogate. However, due to their nonclonal nature, INS-1… (More)
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Highly Cited
2001
Highly Cited
2001
Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no… (More)
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Highly Cited
2000
Highly Cited
2000
The biochemical mechanisms involved in regulation of insulin secretion are not completely understood. The rat INS-1 cell line has… (More)
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Highly Cited
1998
Highly Cited
1998
High concentrations of glucose are considered to be toxic for the pancreatic beta-cell. However, the mechanisms underlying beta… (More)
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Highly Cited
1998
Highly Cited
1998
ATP-sensitive K+ (KATP) channels regulate many cellular functions by linking cell metabolism to membrane potential. We have… (More)
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Highly Cited
1998
Highly Cited
1998
We took advantage of the partial protection exerted by suitable dosages of nicotinamide against the beta-cytotoxic effect of… (More)
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Highly Cited
1996
Highly Cited
1996
Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for… (More)
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Highly Cited
1986
Highly Cited
1986
The influence of the antidiabetic sulphonylurea tolbutamide on K+ channels of mouse pancreatic β-cells was investigated using… (More)
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