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Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
BACKGROUND Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin… Expand
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Highly Cited
2001
Highly Cited
2001
St John's wort(Hypericum perforatum) is a popular over‐the‐counter dietary supplement and herbal remedy that has been implicated… Expand
Highly Cited
2000
Highly Cited
2000
The biochemical mechanisms involved in regulation of insulin secretion are not completely understood. The rat INS-1 cell line has… Expand
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Highly Cited
1998
Highly Cited
1998
High concentrations of glucose are considered to be toxic for the pancreatic beta-cell. However, the mechanisms underlying beta… Expand
Review
1998
Review
1998
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug metabolizing enzymes in humans. Substrates for… Expand
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Highly Cited
1998
Highly Cited
1998
We took advantage of the partial protection exerted by suitable dosages of nicotinamide against the β-cytotoxic effect of… Expand
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Highly Cited
1996
Highly Cited
1996
Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for… Expand
Review
1989
Review
1989
Glucose tolerance depends on a complex interaction among insulin secretion from the β-cells, clearance of the hormone, and the… Expand
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Highly Cited
1966
Highly Cited
1966
Plasma insulin responses to oral glucose (100 gm.) and intravenous tolbutamide (1.0 gm.) before and after dexamethasone were… Expand
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