Skip to search formSkip to main contentSkip to account menu

Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… 
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (11)

4'-hydroxytolbutamideArtosinDiabetolDiaval

Broader (3)

AntidiabeticsHypoglycemic AgentsSulfonylurea Compounds
Diabetes Mellitus, Non-Insulin-DependentIn BloodPregnancyTolbutamide sodium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1984
Highly Cited
1984
Crystallinity and dissolution rate of tolbutamide solid dispersions prepared by the melt method.
The influence of cooling rate of solid dispersions prepared by the melt method was studied by X-ray diffraction and scanning… 
1984
1984
Tolbutamide Stimulates Fructose-2, 6-Bisphosphate Formation in Perfused Rat Liver
Effect of tolbutamide on liver fructose-2,6-bisphosphate (F-2,6-P2) was examined in isolated perfused rat liver in situ with a… 
Highly Cited
1980
Highly Cited
1980
Potentiation of Insulin Secretion to Nonglucose Stimuli in Normal Man by Tolbutamide
To determine how sulfonylureas affect beta cell function, insulin release in response to isoproterenol and arginine was assessed… 
Highly Cited
1972
Highly Cited
1972
Effect of chronic sulfonylurea therapy on plasma insulin and proinsulin levels.
ABSTRACT The effect of the chronic administration of glyburide, a potent sulfonylurea, on plasma glucose, insulin and proinsulin… 
Highly Cited
1971
Highly Cited
1971
Effects of Gestational Age, Birth and Feeding on the Insulinogenic Response to Glucose and Tolbutamide by Fetal and Newborn Rat Pancreas
Perinatal maturation of the pancreatic beta cells was studied in the rat. Insulin synthesis proceeded rapidly be tween the… 
Highly Cited
1968
Highly Cited
1968
Hypernatremia due to hypodipsia and elevated threshold for vasopressin release. Effects of treatment with hydrochlorothiazide, chlorpropamide and tolbutamide.
Abstract A woman previously operated for craniopharyngioma has chronic hypernatremia without polyuria or polydipsia. The… 
Highly Cited
1967
Highly Cited
1967
Potentiation of acetohexamide hypoglycemia by phenylbutazone.
PROLONGED and profound hypoglycemia has occasionally been reported in patients who have been taking the sulfonylurea agents.1 2 3… 
1965
1965
Long-term Observations on Oral Hypoglycemic Agents in Diabetes: The Effect of Carbutamide and Tolbutamide
On the basis of a six-year investigation in which 9,214 diabetics were treated with oral agents, we were able to confirm the… 
Highly Cited
1963
Highly Cited
1963
Disappearance Rate of Tolbutamide in Normal Subjects and in Diabetes Mellitus, Liver Cirrhosis, and Renal Disease
In order to elucidate the mechanism of the hypoglycemic action of tolbutamide, it is important to understand the metabolism of… 
1959
1959
Secondary failure of response to tolbutamide treatment.
A group of 200 patients with diabetes mellitus were observed for periods of many months as to their response to continued…