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Tolbutamide
Known as:
N-(4-Methylphenylsulfonyl)-n'-butylurea
, 1-Butyl-3-(P-tolylsulfonyl)urea
, N-Butyl-n'-P-toluenesulfonylurea
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A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to…
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National Institutes of Health
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Related topics
Related topics
28 relations
Narrower (11)
4'-hydroxytolbutamide
Artosin
Diabetol
Diaval
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Broader (3)
Antidiabetics
Hypoglycemic Agents
Sulfonylurea Compounds
Diabetes Mellitus, Non-Insulin-Dependent
In Blood
Pregnancy
Tolbutamide sodium
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Glucose Sensing in L Cells: A Primary Cell Study
F. Reimann
,
A. M. Habib
,
G. Tolhurst
,
H. Parker
,
G. Rogers
,
F. Gribble
Cell metabolism
2008
Corpus ID: 6061927
Review
2005
Review
2005
Clinical Consequences of Cytochrome P450 2C9 Polymorphisms
J. Kirchheiner
,
J. Brockmöller
Clinical pharmacology and therapeutics
2005
Corpus ID: 45365027
Highly Cited
2004
Highly Cited
2004
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
A. Gloyn
,
E. Pearson
,
+22 authors
A. Hattersley
The New England journal of medicine
2004
Corpus ID: 11237649
BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin…
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Highly Cited
2003
Highly Cited
2003
Genetic cause of hyperglycaemia and response to treatment in diabetes
E. Pearson
,
B. Starkey
,
R. Powell
,
F. Gribble
,
P. Clark
,
A. Hattersley
The Lancet
2003
Corpus ID: 34914098
Highly Cited
2001
Highly Cited
2001
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity
Zaiqi Wang
,
J. Gorski
,
M. Hamman
,
Shiew-Mei Huang
,
L. Lesko
,
S. Hall
Clinical pharmacology and therapeutics
2001
Corpus ID: 25251076
Highly Cited
1998
Highly Cited
1998
Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration.
I. Efanova
,
S. Zaitsev
,
+4 authors
P. Berggren
The Journal of biological chemistry
1998
Corpus ID: 24894642
High concentrations of glucose are considered to be toxic for the pancreatic beta-cell. However, the mechanisms underlying beta…
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Highly Cited
1996
Highly Cited
1996
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.
T. Sullivan-Klose
,
B. Ghanayem
,
+6 authors
J. Goldstein
Pharmacogenetics
1996
Corpus ID: 25088592
Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for…
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Highly Cited
1995
Highly Cited
1995
Cloning and functional expression of the cDNA encoding a novel ATP‐sensitive potassium channel subunit expressed in pancreatic β‐cells, brain, heart and skeletal muscle
H. Sakura
,
C. Ammälä
,
P. Smith
,
F. Gribble
,
F. Ashcroft
FEBS letters
1995
Corpus ID: 8774350
Highly Cited
1985
Highly Cited
1985
THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL
N. Sturgess
,
D. Cook
,
Michael L.J. Ashford
,
C. Hales
The Lancet
1985
Corpus ID: 38037127
Highly Cited
1966
Highly Cited
1966
Plasma Insulin Responses to Glucose and Tolbutamide of Normal Weight and Obese Diabetic and Nondiabetic Subjects
M. Perley
,
D. Kipnis
Diabetes
1966
Corpus ID: 29223062
Plasma insulin responses to oral glucose (100 gm.) and intravenous tolbutamide (1.0 gm.) before and after dexamethasone were…
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