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Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… 
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (11)

4'-hydroxytolbutamideArtosinDiabetolDiaval

Broader (3)

AntidiabeticsHypoglycemic AgentsSulfonylurea Compounds
Diabetes Mellitus, Non-Insulin-DependentIn BloodPregnancyTolbutamide sodium

Papers overview

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Highly Cited
2008
Highly Cited
2008
Glucose Sensing in L Cells: A Primary Cell Study
Review
2005
Review
2005
Clinical Consequences of Cytochrome P450 2C9 Polymorphisms
Highly Cited
2004
Highly Cited
2004
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin… 
Highly Cited
2003
Highly Cited
2003
Genetic cause of hyperglycaemia and response to treatment in diabetes
Highly Cited
2001
Highly Cited
2001
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity
Highly Cited
1998
Highly Cited
1998
Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration.
High concentrations of glucose are considered to be toxic for the pancreatic beta-cell. However, the mechanisms underlying beta… 
Highly Cited
1996
Highly Cited
1996
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.
Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for… 
Highly Cited
1995
Highly Cited
1995
Cloning and functional expression of the cDNA encoding a novel ATP‐sensitive potassium channel subunit expressed in pancreatic β‐cells, brain, heart and skeletal muscle
Highly Cited
1985
Highly Cited
1985
THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL
Highly Cited
1966
Highly Cited
1966
Plasma Insulin Responses to Glucose and Tolbutamide of Normal Weight and Obese Diabetic and Nondiabetic Subjects
Plasma insulin responses to oral glucose (100 gm.) and intravenous tolbutamide (1.0 gm.) before and after dexamethasone were… 
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