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Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… 
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (11)

4'-hydroxytolbutamideArtosinDiabetolDiaval

Broader (3)

AntidiabeticsHypoglycemic AgentsSulfonylurea Compounds
Diabetes Mellitus, Non-Insulin-DependentIn BloodPregnancyTolbutamide sodium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell.
Highly Cited
1998
Highly Cited
1998
Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans.
Highly Cited
1997
Highly Cited
1997
Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples.
Omeprazole 5-hydroxylation and sulfoxidation activities were determined in liver microsomes of different humans whose levels of… 
Highly Cited
1990
Highly Cited
1990
Simultaneous recordings of glucose dependent electrical activity and ATP‐regulated K+‐currents in isolated mouse pancreatic β‐cells
Highly Cited
1989
Highly Cited
1989
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Highly Cited
1988
Highly Cited
1988
Characterization of the sulfonylurea receptor on beta cell membranes.
Highly Cited
1987
Highly Cited
1987
Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.
Highly Cited
1985
Highly Cited
1985
THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL
Highly Cited
1969
Highly Cited
1969
Inhibition of drug metabolism by chloramphenicol.
Highly Cited
1964
Highly Cited
1964
HYPERLIPEMIA AND KETOSIS IN THE PREGNANT RAT.
Pregnant rats fasted on the 18th or 19th day of gestation developed hypoglycemia, severe ketosis, and hyperlipemia. The latter… 
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