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Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… Expand
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (11)

4'-hydroxytolbutamideArtosinDiabetolDiaval
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Broader (3)

AntidiabeticsHypoglycemic AgentsSulfonylurea Compounds
Diabetes Mellitus, Non-Insulin-DependentIn BloodPregnancyTolbutamide sodium
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
BACKGROUND Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP… Expand
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Highly Cited
2004
Highly Cited
2004
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin… Expand
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Highly Cited
2001
Highly Cited
2001
The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity
St John's wort(Hypericum perforatum) is a popular over‐the‐counter dietary supplement and herbal remedy that has been implicated… Expand
Highly Cited
2000
Highly Cited
2000
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.
The biochemical mechanisms involved in regulation of insulin secretion are not completely understood. The rat INS-1 cell line has… Expand
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Highly Cited
1998
Highly Cited
1998
Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration.
High concentrations of glucose are considered to be toxic for the pancreatic beta-cell. However, the mechanisms underlying beta… Expand
Review
1998
Review
1998
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism.
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug metabolizing enzymes in humans. Substrates for… Expand
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Highly Cited
1998
Highly Cited
1998
Experimental NIDDM: Development of a New Model in Adult Rats Administered Streptozotocin and Nicotinamide
We took advantage of the partial protection exerted by suitable dosages of nicotinamide against the β-cytotoxic effect of… Expand
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Highly Cited
1996
Highly Cited
1996
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.
Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for… Expand
Review
1989
Review
1989
Toward Physiological Understanding of Glucose Tolerance: Minimal-Model Approach
Glucose tolerance depends on a complex interaction among insulin secretion from the β-cells, clearance of the hormone, and the… Expand
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Highly Cited
1966
Highly Cited
1966
Plasma Insulin Responses to Glucose and Tolbutamide of Normal Weight and Obese Diabetic and Nondiabetic Subjects
Plasma insulin responses to oral glucose (100 gm.) and intravenous tolbutamide (1.0 gm.) before and after dexamethasone were… Expand
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