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Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… 
National Institutes of Health

Papers overview

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Highly Cited
2008
Review
2005
Review
2005
Highly Cited
2004
Highly Cited
2004
BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin… 
Highly Cited
2001
Highly Cited
1998
Highly Cited
1998
High concentrations of glucose are considered to be toxic for the pancreatic beta-cell. However, the mechanisms underlying beta… 
Highly Cited
1996
Highly Cited
1996
Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for… 
Highly Cited
1966
Highly Cited
1966
Plasma insulin responses to oral glucose (100 gm.) and intravenous tolbutamide (1.0 gm.) before and after dexamethasone were…