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Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Summary Glucagon-like peptide-1 (GLP-1) is an enteric hormone that stimulates insulin secretion and improves glycaemia in type 2… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin… Expand
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Highly Cited
2004
Highly Cited
2004
Rat insulinoma-derived INS-1 cells constitute a widely used beta-cell surrogate. However, due to their nonclonal nature, INS-1… Expand
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Highly Cited
2001
Highly Cited
2001
Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no… Expand
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Highly Cited
2000
Highly Cited
2000
The biochemical mechanisms involved in regulation of insulin secretion are not completely understood. The rat INS-1 cell line has… Expand
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Highly Cited
1998
Highly Cited
1998
High concentrations of glucose are considered to be toxic for the pancreatic beta-cell. However, the mechanisms underlying beta… Expand
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Review
1998
Review
1998
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug metabolizing enzymes in humans. Substrates for… Expand
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Highly Cited
1998
Highly Cited
1998
We took advantage of the partial protection exerted by suitable dosages of nicotinamide against the β-cytotoxic effect of… Expand
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Highly Cited
1996
Highly Cited
1996
Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for… Expand
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