FAQ

Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… (More)

Topic mentions per year

Topic mentions per year

1955-2018
05010019552017

Related topics

Related topics

21 relations

Narrower (8)

4'-hydroxytolbutamideArtosinDiabetolDolipol
(More)

Broader (3)

AntidiabeticsHypoglycemic AgentsSulfonylurea Compounds
Diabetes Mellitus, Non-Insulin-DependentIn BloodPregnancyadministration & dosage
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Tolbutamide
Diabetes Mellitus, Non-Insulin-Dependent
agonists
Pregnancy
Hypoglycemic Agents
Antidiabetics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
BACKGROUND Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP… (More)
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Highly Cited
2004
Highly Cited
2004
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin… (More)
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Highly Cited
2004
Highly Cited
2004
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.
Rat insulinoma-derived INS-1 cells constitute a widely used beta-cell surrogate. However, due to their nonclonal nature, INS-1… (More)
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Highly Cited
2001
Highly Cited
2001
Longitudinal study on pubertal insulin resistance.
Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no… (More)
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Highly Cited
2000
Highly Cited
2000
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.
The biochemical mechanisms involved in regulation of insulin secretion are not completely understood. The rat INS-1 cell line has… (More)
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Highly Cited
1998
Highly Cited
1998
Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration.
High concentrations of glucose are considered to be toxic for the pancreatic beta-cell. However, the mechanisms underlying beta… (More)
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Highly Cited
1998
Highly Cited
1998
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
ATP-sensitive K+ (KATP) channels regulate many cellular functions by linking cell metabolism to membrane potential. We have… (More)
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Highly Cited
1998
Highly Cited
1998
Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide.
We took advantage of the partial protection exerted by suitable dosages of nicotinamide against the beta-cytotoxic effect of… (More)
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Highly Cited
1996
Highly Cited
1996
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.
Tolbutamide undergoes hydroxylation in humans via a cytochrome P450-mediated pathway. The primary P450 isozyme responsible for… (More)
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Highly Cited
1986
Highly Cited
1986
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells
The influence of the antidiabetic sulphonylurea tolbutamide on K+ channels of mouse pancreatic β-cells was investigated using… (More)
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