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Tolbutamide

Known as: N-(4-Methylphenylsulfonyl)-n'-butylurea, 1-Butyl-3-(P-tolylsulfonyl)urea, N-Butyl-n'-P-toluenesulfonylurea 
A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to… 
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (11)

4'-hydroxytolbutamideArtosinDiabetolDiaval

Broader (3)

AntidiabeticsHypoglycemic AgentsSulfonylurea Compounds
Diabetes Mellitus, Non-Insulin-DependentIn BloodPregnancyTolbutamide sodium

Papers overview

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Highly Cited
1984
Highly Cited
1984
Crystallinity and dissolution rate of tolbutamide solid dispersions prepared by the melt method.
The influence of cooling rate of solid dispersions prepared by the melt method was studied by X-ray diffraction and scanning… 
Highly Cited
1980
Highly Cited
1980
Potentiation of Insulin Secretion to Nonglucose Stimuli in Normal Man by Tolbutamide
To determine how sulfonylureas affect beta cell function, insulin release in response to isoproterenol and arginine was assessed… 
Highly Cited
1972
Highly Cited
1972
Effect of chronic sulfonylurea therapy on plasma insulin and proinsulin levels.
ABSTRACT The effect of the chronic administration of glyburide, a potent sulfonylurea, on plasma glucose, insulin and proinsulin… 
Highly Cited
1971
Highly Cited
1971
Effects of Gestational Age, Birth and Feeding on the Insulinogenic Response to Glucose and Tolbutamide by Fetal and Newborn Rat Pancreas
Perinatal maturation of the pancreatic beta cells was studied in the rat. Insulin synthesis proceeded rapidly be tween the… 
1971
1971
Insulin Secretion Studied in the Perfused Rat Pancreas: I. Effect of Tolbutamide, Leucine and Arginine; Their Interaction with Diazoxide, and Relation to Glucose
Glucose produced a diphasic pattern of insulin secretion in the perfused rat pancreas. Both phases were blocked by diazoxide… 
1971
1971
Energy Metabolism in Pancreatic Islets of Rats: Studies with Tolbutamide and Hypoxia
Levels of ATP, phosphocreatine, glycogen and glucose of individual pancreatic islets were measured by quantitative histochemical… 
1965
1965
Long-term Observations on Oral Hypoglycemic Agents in Diabetes: The Effect of Carbutamide and Tolbutamide
On the basis of a six-year investigation in which 9,214 diabetics were treated with oral agents, we were able to confirm the… 
Highly Cited
1965
Highly Cited
1965
Reduced Glucose Tolerance in Elderly Human Subjects
The high incidence of “abnormal” oral glucose tolerance tests in “normal” subjects over seventy years of age has been confirmed… 
Highly Cited
1963
Highly Cited
1963
Disappearance Rate of Tolbutamide in Normal Subjects and in Diabetes Mellitus, Liver Cirrhosis, and Renal Disease
In order to elucidate the mechanism of the hypoglycemic action of tolbutamide, it is important to understand the metabolism of… 
1958
1958
Action of Insulin and Tolbutamide on Blood Glucose Entry and Removal
Although it is generally recognized that the blood sugar of the fasting animal is maintained constant by a precise balance…