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Titin Kinase

Known as: Kinase, Titin, Titin 
 
National Institutes of Health

Related topics

Related topics

4 relations
TTN geneTTN protein, humanTitin Ab:PrThr:Pt:Ser:Ord:IA

Broader (1)

connectin

Papers overview

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2017
2017
&agr;-B Crystallin Reverses High Diastolic Stiffness of Failing Human Cardiomyocytes
Background— Cardiomyocytes with a less distensible titin and interstitial collagen contribute to the high diastolic stiffness of… Expand
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2015
2015
Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling.
We investigated the cellular and molecular mechanisms of diastolic dysfunction in pure volume overload induced by aortocaval… Expand
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2015
2015
Role of Titin Missense Variants in Dilated Cardiomyopathy
BACKGROUND The titin gene (TTN) encodes the largest human protein, which plays a central role in sarcomere organization and… Expand
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2014
2014
Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo.
BACKGROUND We explored a function for tropomyosin (TM) in mammalian myofibril assembly and cardiac development by analyzing a… Expand
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2010
2010
Exploring the conformation-regulated function of titin kinase by mechanical pump and probe experiments with single molecules.
Protein function such as catalytic activity or molecular recognition is tightly coupled to the conformation and dynamics. Since… Expand
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2009
2009
Altered contractility of skeletal muscle in mice deficient in titin's M-band region.
We investigated the contractile phenotype of skeletal muscle deficient in exons MEx1 and MEx2 (KO) of the titin M-band by using… Expand
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2003
2003
The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin.
Little is known about the mechanisms that organize the internal membrane systems in eukaryotic cells. We are addressing this… Expand
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Highly Cited
2002
Highly Cited
2002
Different regional effects of voluntary exercise on the mechanical and electrical properties of rat ventricular myocytes.
Short-term (6 weeks) voluntary wheel running exercise in young female rats that were in an active growth phase resulted in whole… Expand
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2001
2001
Structural and functional studies of titin's fn3 modules reveal conserved surface patterns and binding to myosin S1--a possible role in the Frank-Starling mechanism of the heart.
The A-band part of titin, a striated-muscle specific protein spanning from the Z-line to the M-line, mainly consists of a well… Expand
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Highly Cited
1998
Highly Cited
1998
The NH2 Terminus of Titin Spans the Z-Disc: Its Interaction with a Novel 19-kD Ligand (T-cap) Is Required for Sarcomeric Integrity
Titin is a giant elastic protein in vertebrate striated muscles with an unprecedented molecular mass of 3-4 megadaltons. Single… Expand
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