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TTN protein, human

Known as: CMD1G protein, human, EC 2.7.11.1, Titin 
Titin (34350 aa, ~3816 kDa) is encoded by the human TTN gene. This protein plays a role in muscle filament structure and contraction.
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the… Expand
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Highly Cited
2005
Highly Cited
2005
The active and passive contractile performance of skeletal muscle fibers largely depends on the myosin heavy chain (MHC) isoform… Expand
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Highly Cited
2005
Highly Cited
2005
The conversion of mechanical stress into a biochemical signal in a muscle cell requires a force sensor. Titin kinase, the… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVES We sought to explore the relationship between a Tcap gene (TCAP) abnormality and cardiomyopathy. BACKGROUND… Expand
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Highly Cited
2002
Highly Cited
2002
Background—Ischemia-induced cardiomyopathy usually is accompanied by elevated left ventricular end-diastolic pressure, which… Expand
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Highly Cited
2002
Highly Cited
2002
&bgr;-Adrenergic stimulation of cardiac muscle activates protein kinase A (PKA), which is known to phosphorylate proteins on the… Expand
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Highly Cited
1999
Highly Cited
1999
In cardiac muscle, the giant protein titin exists in different length isoforms expressed in the molecule's I-band region. Both… Expand
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Highly Cited
1996
Highly Cited
1996
Vertebrate striated muscle behaves elastically when stretched and this property is thought to reside primarily within the giant… Expand
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Highly Cited
1995
Highly Cited
1995
p94, a muscle-specific member of calpain family, is unique in that it undergoes rapid and exhaustive autolysis with a half-life… Expand
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Highly Cited
1991
Highly Cited
1991
To explore the role of titin filaments in muscle elasticity, we measured the resting tension-sarcomere length curves of six… Expand
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