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Tissue Inhibitor of Metalloproteinases
Known as:
Proteins, TIMP
, TIMP Proteins
, TIMP
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A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role…
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National Institutes of Health
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Related topics
Related topics
22 relations
Collagenase Inhibitor
Genes, Regulator
In Blood
Prinicpal result interpreter:Pn:Pt:Study:Nom
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Broader (3)
Glycoproteins
Matrix Metalloproteinase Inhibitors
Protease Inhibitors
Narrower (4)
TIMP protein, Crassostrea gigas
TIMP1 protein, human
Tissue-Inhibitor of Metalloproteinase-1
tissue inhibitor of metalloproteinase 4
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Cardiovascular , Pulmonary and Renal Pathology CCR 5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart , Mediating Recruitment of Regulatory T Cells
M. Dobaczewski
,
Ying Xia
,
Marcin Bujak
,
C. Gonzalez-Quesada
,
N. Frangogiannis
2010
Corpus ID: 19951009
Myocardial infarction triggers an inflammatory reaction that is involved in cardiac remodeling. Cardiac repair is dependent on…
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Highly Cited
2003
Highly Cited
2003
Involvement of the Erk-MAP kinase pathway in TNFalpha regulation of trabecular matrix metalloproteinases and TIMPs.
J. Alexander
,
T. Acott
Investigative Ophthalmology and Visual Science
2003
Corpus ID: 23304388
PURPOSE TNFalpha is a strong modulator expression of trabecular meshwork (TM) matrix metalloproteinase (MMP) and tissue inhibitor…
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Highly Cited
2000
Highly Cited
2000
Identification of matrix metalloproteinases in canine neoplastic tissue.
S. E. Lana
,
Gregory K. Ogilvie
,
R. A. Hansen
,
Barbara E. Powers
,
W. Dernell
,
S. J. Withrow
American Journal of Veterinary Research
2000
Corpus ID: 22406037
OBJECTIVE To identify matrix metalloproteinases (MMP) 2 and 9 in canine tumor tissue and to compare the amount of activity to…
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Highly Cited
1998
Highly Cited
1998
Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor
P. Hargreaves
,
Fengfei Wang
,
+4 authors
P. Croucher
British Journal of Haematology
1998
Corpus ID: 46736162
Interleukin‐6 (IL‐6) is the major growth factor for human myeloma cells, exerting its effect through the IL‐6 receptor (IL‐6R). A…
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Highly Cited
1998
Highly Cited
1998
Immunohistochemical analysis of several proteolytic enzymes as parameters of cartilage degradation.
H. Walter
,
A. Kawashima
,
W. Nebelung
,
W. Neumann
,
A. Roessner
Pathology, Research and Practice
1998
Corpus ID: 19773010
Highly Cited
1998
Highly Cited
1998
Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon…
Mark A. Lombard
,
T. L. Wallace
,
+4 authors
J. Wilks
Cancer Research
1998
Corpus ID: 34463743
The solubilization of plasma membrane receptors through proteolytic cleavage of the ligand binding domain at the cell surface is…
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Highly Cited
1992
Highly Cited
1992
Matrix vesicles are enriched in metalloproteinases that degrade proteoglycans
D. Dean
,
Z. Schwartz
,
+4 authors
B. Boyan
Calcified Tissue International
1992
Corpus ID: 27293132
SummaryThis study examined the presence of extracellular matrix processing enzymes in matrix vesicles produced by rat…
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Highly Cited
1990
Highly Cited
1990
cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.
T. Boone
,
M. J. Johnson
,
Y. Clerck
,
K. Langley
Proceedings of the National Academy of Sciences…
1990
Corpus ID: 22732494
The purification and characterization of a metalloproteinase inhibitor (MI) from bovine aortic endothelial cells, and the…
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Highly Cited
1983
Highly Cited
1983
Production of collagenase and inhibitor (TIMP) by intracranial tumors and dura in vitro.
A. Halaka
,
R. Bunning
,
C. Bird
,
M. Gibson
,
J. Reynolds
Journal of Neurosurgery
1983
Corpus ID: 24035193
The production of collagenase and collagenase inhibitor (TIMP) by various intracranial tumors (25 meningiomas, eight gliomas…
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Highly Cited
1981
Highly Cited
1981
Production of collagenase and inhibitor (TIMP) by normal, rheumatoid and osteoarthritic synovium in vitro: effects of hydrocortisone and indomethacin.
M. McGuire
,
G. Murphy
,
J. Reynolds
,
R. Russell
Clinical science
1981
Corpus ID: 39829573
1. The amounts of latent and active collagenase and of collagenase inhibitor (TIMP) produced by two normal, three rheumatoid and…
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