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Tissue Inhibitor of Metalloproteinases

Known as: Proteins, TIMP, TIMP Proteins, TIMP 
A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role… 
National Institutes of Health

Related topics

Related topics

22 relations
Collagenase InhibitorGenes, RegulatorIn BloodPrinicpal result interpreter:Pn:Pt:Study:Nom

Broader (3)

GlycoproteinsMatrix Metalloproteinase InhibitorsProtease Inhibitors

Narrower (4)

TIMP protein, Crassostrea gigasTIMP1 protein, humanTissue-Inhibitor of Metalloproteinase-1tissue inhibitor of metalloproteinase 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Cardiovascular , Pulmonary and Renal Pathology CCR 5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart , Mediating Recruitment of Regulatory T Cells
Myocardial infarction triggers an inflammatory reaction that is involved in cardiac remodeling. Cardiac repair is dependent on… 
Highly Cited
2003
Highly Cited
2003
Involvement of the Erk-MAP kinase pathway in TNFalpha regulation of trabecular matrix metalloproteinases and TIMPs.
PURPOSE TNFalpha is a strong modulator expression of trabecular meshwork (TM) matrix metalloproteinase (MMP) and tissue inhibitor… 
Highly Cited
2000
Highly Cited
2000
Identification of matrix metalloproteinases in canine neoplastic tissue.
OBJECTIVE To identify matrix metalloproteinases (MMP) 2 and 9 in canine tumor tissue and to compare the amount of activity to… 
Highly Cited
1998
Highly Cited
1998
Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor
Interleukin‐6 (IL‐6) is the major growth factor for human myeloma cells, exerting its effect through the IL‐6 receptor (IL‐6R). A… 
Highly Cited
1998
Highly Cited
1998
Immunohistochemical analysis of several proteolytic enzymes as parameters of cartilage degradation.
Highly Cited
1998
Highly Cited
1998
Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon…
The solubilization of plasma membrane receptors through proteolytic cleavage of the ligand binding domain at the cell surface is… 
Highly Cited
1992
Highly Cited
1992
Matrix vesicles are enriched in metalloproteinases that degrade proteoglycans
SummaryThis study examined the presence of extracellular matrix processing enzymes in matrix vesicles produced by rat… 
Highly Cited
1990
Highly Cited
1990
cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.
The purification and characterization of a metalloproteinase inhibitor (MI) from bovine aortic endothelial cells, and the… 
Highly Cited
1983
Highly Cited
1983
Production of collagenase and inhibitor (TIMP) by intracranial tumors and dura in vitro.
The production of collagenase and collagenase inhibitor (TIMP) by various intracranial tumors (25 meningiomas, eight gliomas… 
Highly Cited
1981
Highly Cited
1981
Production of collagenase and inhibitor (TIMP) by normal, rheumatoid and osteoarthritic synovium in vitro: effects of hydrocortisone and indomethacin.
1. The amounts of latent and active collagenase and of collagenase inhibitor (TIMP) produced by two normal, three rheumatoid and… 
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