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Tissue Inhibitor of Metalloproteinases

Known as: Proteins, TIMP, TIMP Proteins, TIMP 
A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role… Expand
National Institutes of Health

Related topics

Related topics

22 relations
Collagenase InhibitorGenes, RegulatorIn BloodPrinicpal result interpreter:Pn:Pt:Study:Nom
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Broader (3)

GlycoproteinsMatrix Metalloproteinase InhibitorsProtease Inhibitors

Narrower (4)

TIMP protein, Crassostrea gigasTIMP1 protein, humanTissue-Inhibitor of Metalloproteinase-1tissue inhibitor of metalloproteinase 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
Macrophages and inflammation play a beneficial role during wound repair with macrophages regulating a wide range of processes… Expand
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Highly Cited
2007
Highly Cited
2007
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves.
OBJECTIVE The mechanisms contributing to ascending thoracic aortic aneurysms associated with bicuspid aortic valves may differ… Expand
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Highly Cited
2005
Highly Cited
2005
Age-dependent changes in myocardial matrix metalloproteinase/tissue inhibitor of metalloproteinase profiles and fibroblast function.
OBJECTIVE To evaluate the effects of aging on left ventricular (LV) geometry, collagen levels, matrix metalloproteinase (MMP) and… Expand
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Highly Cited
2001
Highly Cited
2001
Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression.
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder characterized by fibroblast proliferation and extracellular matrix… Expand
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Highly Cited
1998
Highly Cited
1998
Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells.
We have used adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinase (TIMP)-1, -2, and -3 to examine their… Expand
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Highly Cited
1997
Highly Cited
1997
Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta.
BACKGROUND Abdominal aortic aneurysms (AAAs) are characterized by degradation of collagen and elastin resulting from increases in… Expand
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Highly Cited
1996
Highly Cited
1996
Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver.
BACKGROUND & AIMS Tissue inhibitors of metalloproteinases may contribute to liver fibrosis by preventing remodeling of fibrillar… Expand
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Highly Cited
1994
Highly Cited
1994
Inhibition of angiogenesis by tissue inhibitor of metalloproteinase.
Matrix proteases play a critical role in cell invasion and migration, including the process of angiogenesis. The ability of… Expand
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Highly Cited
1989
Highly Cited
1989
Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family.
Human melanoma cells secret a 21-kDa protein, termed CSC-21K, which binds with 1:1 molar stoichiometry to the matrix… Expand
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Highly Cited
1985
Highly Cited
1985
Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity
Collagen fibres form the stable architecture of connective tissues and their breakdown is a key irreversible step in many… Expand
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