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Tissue-Inhibitor of Metalloproteinase-1

Known as: TIMP-1, Tissue Inhibitor of Metalloproteinase-1, Metalloproteinase-1 Tissue Inhibitor 
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of… 
National Institutes of Health

Related topics

Related topics

15 relations
Collagenase InhibitorIn BloodProcess of secretionTIMP1 gene

Broader (3)

GlycoproteinsMatrix Metalloproteinase InhibitorsTissue Inhibitor of Metalloproteinases

Narrower (1)

TIMP1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Elevated plasma tissue inhibitor of metalloproteinase‐1 levels predict decreased survival in castration‐resistant prostate cancer patients
Tissue inhibitor of metalloproteinase‐1 (TIMP‐1) has paradoxical multifunctional roles in tumorigenesis: inhibition of the… 
Highly Cited
2008
Highly Cited
2008
Ciglitazone, a PPARgamma agonist, ameliorates diabetic nephropathy in part through homocysteine clearance.
Diabetes and hyperhomocysteinemia (HHcy) are two independent risk factors for glomeruloslerosis and renal insufficiency. Although… 
2004
2004
Proteolytic imbalance is reversed after therapeutic surgery in breast cancer patients
The occurrence of metastasis severely affects prognosis and survival of breast cancer patients. In order to metastasize, breast… 
Highly Cited
2004
Highly Cited
2004
TIMP-1 Alters Susceptibility to Carcinogenesis
Tissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins known to possess a broad range of… 
2004
2004
Exogenous Tissue Inhibitor of Metalloproteinase‐1 Promotes Endothelial Cell Survival Through Activation of the Phosphatidylinositol 3‐Kinase/Akt Pathway
Abstract: Control of molecular targets and signaling pathways which improve endothelial cell survival may be an attractive… 
Highly Cited
2003
Highly Cited
2003
TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src.
2002
2002
Analysis of Luteal Tissue Inhibitor of Metalloproteinase-1, -2, and -3 During Prostaglandin F2α-Induced Luteolysis1
Abstract Increased matrix metalloproteinase (MMP) expression and activities help to mediate tissue involution through increasing… 
2002
2002
Expression of matrix metalloproteinase ‐2, ‐9 and tissue inhibitors of metalloproteinase ‐1, ‐2, ‐3 mRNAs in rat uterus during early pregnancy
Zymography and in situ hybridizition were used to investigate matrix metalloproteinase‐2, ‐9 (MMP‐2, ‐9) activities, and… 
Highly Cited
1998
Highly Cited
1998
Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin‐binding EGF‐like growth factor independently of protein kinase C
The phorbol ester, tetradecanoyl‐phorbol 13‐acetate (TPA), stimulates rapid proteolytic processing of the transmembrane, pro… 
Highly Cited
1993
Highly Cited
1993
Clinical evaluation of serum tissue inhibitor of metalloproteinases‐1 levels in patients with liver diseases
Serum levels of the tissue inhibitor of metalloproteinases‐1 (TIMP‐1) were measured in 268 patients with liver diseases by means… 
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