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Tissue-Inhibitor of Metalloproteinase-1

Known as: TIMP-1, Tissue Inhibitor of Metalloproteinase-1, Metalloproteinase-1 Tissue Inhibitor 
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of… 
National Institutes of Health

Related topics

Related topics

15 relations
Collagenase InhibitorIn BloodProcess of secretionTIMP1 gene

Broader (3)

GlycoproteinsMatrix Metalloproteinase InhibitorsTissue Inhibitor of Metalloproteinases

Narrower (1)

TIMP1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Astrocytic Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Promotes Oligodendrocyte Differentiation and Enhances CNS Myelination
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an extracellular protein and endogenous regulator of matrix… 
Highly Cited
2006
Highly Cited
2006
Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension.
There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP… 
Highly Cited
2004
Highly Cited
2004
Antifibrotic effects of a tissue inhibitor of metalloproteinase‐1 antibody on established liver fibrosis in rats
Liver fibrosis is characterized by increased synthesis, and decreased degradation, of extracellular matrix (ECM) within the… 
Highly Cited
2003
Highly Cited
2003
Regulation of tissue inhibitor of metalloproteinase‐1 by astrocytes: Links to HIV‐1 dementia
The neuropathogenesis of HIV‐1‐associated dementia (HAD) revolves around the secretion of toxic molecules from infected and… 
Highly Cited
2002
Highly Cited
2002
Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF
The purpose of this study was to examine the role of interstitial collagenases, members of the family of matrix… 
Highly Cited
2000
Highly Cited
2000
Tissue inhibitor of metalloproteinases‐1 promotes liver fibrosis development in a transgenic mouse model
Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) has been shown to be increased in liver fibrosis development both in murine… 
Highly Cited
1998
Highly Cited
1998
The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45…
We have assessed the effect of fibronectin and laminin-1 on the expression of molecules involved in the activation pathway of MMP… 
Highly Cited
1996
Highly Cited
1996
Tissue inhibitor of metalloproteinase‐1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis
Liver fibrosis results from a relative imbalance between synthesis and degradation of matrix proteins. We have previously… 
Highly Cited
1992
Highly Cited
1992
Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts.
Highly Cited
1991
Highly Cited
1991
The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and…
Human gingival fibroblasts in culture were shown to secrete a 72 kDa progelatinase, of which a proportion in the medium was found… 
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