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Thymidine Phosphorylase

Known as: EC 2.4.2.4, Platelet-Derived Endothelial Cell Growth Factor 1, Platelet Derived Endothelial Cell Growth Factor 
Thymidine phosphorylase (482 aa, ~50 kDa) is encoded by the human TYMP gene. This protein plays a role in pyrimidine metabolism, DNA replication and… 
National Institutes of Health

Related topics

Related topics

25 relations
Angiogenic ProcessCarbohydrate MetabolismEnzyme GeneGlial Cell Proliferation

Broader (1)

pentosyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice.
Replication and repair of DNA require equilibrated pools of deoxynucleoside triphosphate precursors. This concept has been proven… 
Highly Cited
2007
Highly Cited
2007
Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100
The pharmacokinetics of a 2′-O-(2-methoxyethyl)-modified oligonucleotide, ISIS 301012 [targeting human apolipoprotein B-100 (apoB… 
Highly Cited
2003
Highly Cited
2003
Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency.
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by loss-of-function… 
Highly Cited
2002
Highly Cited
2002
Altered Thymidine Metabolism Due to Defects of Thymidine Phosphorylase*
Mitochondrialneurogastrointestinalencephalomyopathy (MNGIE) is an autosomal recessive human disease due to mutations in the… 
Highly Cited
2000
Highly Cited
2000
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
Thymidine phosphorylase (TP) (E.C. 2.4.2.4), also known as platelet-derived endothelial cell growth factor, is a potent… 
Highly Cited
1996
Highly Cited
1996
Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers.
Thymidine phosphorylase (TP), also known as platelet-derived endothelial cell growth factor, has been implicated in bladder… 
Highly Cited
1995
Highly Cited
1995
Different angiogenic pathways characterize superficial and invasive bladder cancer.
We have investigated by RNase protection analysis the expression of 2 angiogenic factors in 45 primary bladder tumors and 8… 
Highly Cited
1995
Highly Cited
1995
Expression of platelet‐derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer
We have investigated the expression of platelet‐derived endothelial‐cell growth factor/thymidine phosphorylase (PD‐ECGF/dThdPase… 
Highly Cited
1993
Highly Cited
1993
Thymidine phosphorylase activity associated with platelet-derived endothelial cell growth factor.
Partial complementary DNA (cDNA) for thymidine phosphorylase (dThdPase) was cloned by means of a polymerase chain reaction. There… 
Highly Cited
1977
Highly Cited
1977
Benzo[a]pyrene diol epoxide covalently binds to deoxyguanosine and deoxyadenosine in DNA
CHEMICAL carcinogens, for example, benzo[a]pyrene (BaP), are metabolised to reactive intermediates which bind covalently to… 
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