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Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.
TLDR
Capecitabine, which is finally converted to 5-FU by dThdPase in tumours, should be much safer and more effective than5-FU, and this was indeed the case in the HCT116 human colon cancer and the MX-1 breast cancer xenograft models. Expand
Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts.
TLDR
Results indicate that capecitabine might exert its efficacy through 5-FUra generated in tumor tissues but not through that generated in normal organs, and would be optimized by selecting patients who have tumors with a high ratio of dThdPase to DPD activities. Expand
Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection
TLDR
A predictive system consisting of 12 genes that predicted early intrahepatic recurrence or non-recurrence for patients with hepatocellular carcinoma much more accurately than the SVM-based system, suggesting that this system could serve as a new method for characterising the metastatic potential of hepatic carcinoma. Expand
Tumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts.
TLDR
Compared the efficacy of capecitabine and 5-FUra at their maximum tolerated doses in CXF280, HCT116, COLO205, and WiDr human colon cancer xenograft models, and measured subsequent 5'-FUra and 5'-dFUrd levels in tumors and in the plasma and muscle, cape citabine might show its high efficacy as a result of delivering high levels of 5'FUra selectively to the tumors. Expand
Induction of thymidine phosphorylase activity and enhancement of capecitabine efficacy by taxol/taxotere in human cancer xenografts.
TLDR
The results suggest that Taxol might indirectly elevate TNFalpha in tumor cells, which in turn up-regulated dThdPase in the tumor cells in the WiDr cancer xenograft model, and enhance the efficacy of capecitabine and 5'-dFUrd. Expand
Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice.
TLDR
Mice bearing colon 26 is an appropriate model for elucidating the mechanism that causes cachexia and noncachectic mice with Meth A fibrosarcoma gained weight, which was somewhat less than the control, and had neither hypoglycemia nor hypercorticism, although some mild disorders of hepatic functions were found. Expand
X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts.
TLDR
Results indicate that X-ray irradiation might increase dThdPase levels indirectly through the human TNF-alpha in the tumor tissue, and combined modality treatment of cancer patients with cape-citabine and X-Ray irradiation would have greater potential usefulness than conventional radiochemotherapy with 5-FUra. Expand
Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues.
TLDR
An ELISA method sensitive enough to measure dThdPase levels, even in tumor tissue samples weighing as little as 10 mg, is developed, which is essential for the activation of 5'-dFUrd. Expand
Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma
TLDR
The results suggest that the serum cfDNA level reflects the metastatic potential of HCV-related HCC and that it can be a useful predictive biomarker for distant metastasis after curative surgery. Expand
Elevated levels of circulating cell-free DNA in the blood of patients with hepatitis C virus-associated hepatocellular carcinoma.
TLDR
Results showed that levels of circulating cell-free DNA are significantly increased in sera of patients with HCV-associated HCC, suggesting that circulate cell- free DNA may be a good biomarker specific for HCV -associated H CC. Expand
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