Thrombasthenia

Known as: glanzmann's disease, PLATELET GLYCOPROTEIN IIb-IIIa DEFICIENCY, Glanzmann's thrombasthenia 
A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Integrins are the major adhesion receptors of leukocytes and platelets. β1 and β2 integrin function on leukocytes is crucial for… (More)
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Review
2006
Review
2006
Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding syndrome affecting the megakaryocyte lineage and… (More)
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Highly Cited
1999
Highly Cited
1999
beta3 integrins have been implicated in a wide variety of functions, including platelet aggregation and thrombosis (alphaIIbbeta3… (More)
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Highly Cited
1996
Highly Cited
1996
The murine/human chimeric monoclonal antibody fragment (c7E3 Fab) blocks GPIIb/IIIa and alpha v beta 3 receptors, inhibits… (More)
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Highly Cited
1991
Highly Cited
1991
Glanzmann thrombasthenia is an autosomal recessive bleeding disorder characterized by a decrease or absence of functional… (More)
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Highly Cited
1983
Highly Cited
1983
To define better the role of the fibrinogen receptor in platelet physiology and to characterize it biochemically, a murine… (More)
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1983
1983
Two hereditary platelet disorders, Bernard-Soulier syndrome and Glanzmann's thrombasthenia, are characterized by selective… (More)
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1982
1982
Glanzmann thrombasthenia is an inherited bleeding disorder characterized by the failure of platelets to aggregate in response to… (More)
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Highly Cited
1980
Highly Cited
1980
We used the hybridoma technique to characterize further the platelet glycoprotein abnormality in Glanzmann's thrombasthenia… (More)
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Highly Cited
1977
Highly Cited
1977
Platelets from patients with Glanzmann's thrombasthenia have a distinct molecular alteration of the plasma membrane surface… (More)
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