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Thrombasthenia

Known as: glanzmann's disease, PLATELET GLYCOPROTEIN IIb-IIIa DEFICIENCY, Glanzmann's thrombasthenia 
A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and… 
National Institutes of Health

Related topics

Related topics

21 relations
Autosomal recessive inheritanceBernard-Soulier SyndromeEpistaxisGastrointestinal Hemorrhage

Broader (1)

Blood Platelet Disorders

Narrower (3)

Glanzmann Thrombasthenia, Autosomal DominantGlanzmann Thrombasthenia, Type ASchlegelberger Grote syndrome

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Glanzmann thrombasthenia in an Oldenbourg filly.
An 18-month-old Oldenbourg filly was presented with a bleeding diathesis. Laboratory testing included platelet count, gingival… 
Review
2000
Review
2000
Glanzmann thrombasthenia: integrin alpha IIb beta 3 deficiency.
Integrins, a family of noncovalently associated alpha beta heterodimeric adhesion receptors, are involved in a variety of… 
1998
1998
A Gln747-->Pro substitution in the IIb subunit is responsible for a moderate IIbbeta3 deficiency in Glanzmann thrombasthenia.
To clarify a molecular defect responsible for moderate alphaIIb beta3 deficiency, we examined two unrelated patients, MT and MS… 
1998
1998
Rapid heterozygote detection in Glanzmann's thrombasthenia
To assess the potential of using flow cytometric analysis of platelet glycoprotein IIb in the detection of heterozygotes in… 
Review
1998
Review
1998
Acquired glanzmann's thrombasthenia associated with hodgkin's lymphoma
Acquired Glanzmann's thrombasthenia is a rare hemorrhagic diathesis resulting from impaired adhesive function of the platelet… 
Highly Cited
1997
Highly Cited
1997
A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro.
Glanzmann thrombasthenia, an inherited bleeding disorder, can be caused by a defect or deficiency in platelet integrin alphaIIb… 
Highly Cited
1985
Highly Cited
1985
Residual amounts of glycoproteins IIb and IIIa may be present in the platelets of most patients with Glanzmann's thrombasthenia.
Glanzmann's thrombasthenia is an inherited bleeding disorder characterized by abnormalities of platelet membrane glycoproteins… 
1983
1983
Monocytes and platelets share the glycoproteins IIb and IIIa that are absent from both cells in Glanzmann's thrombasthenia type I.
By means of an antiserum specific to the complex of the platelet membrane glycoproteins IIb and IIIa we demonstrate here that… 
Highly Cited
1979
Highly Cited
1979
Platelet membrane glycoproteins in thrombasthenia, Bernard-Soulier syndrome, and storage pool disease.
Quantitative polyacrylamide gel electrophoresis has been carried out on patients with Bernard-Soulier syndrome, Glanzmann's… 
1979
1979
alpha-Actinin deficiency in thrombasthenia: possible identity of alpha-actinin and glycoprotein III.
Blood platelets contain a variety of contractile protein species, including the glycoprotein alpha-actinin, which is found at the… 
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