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Thrombasthenia

Known as: glanzmann's disease, PLATELET GLYCOPROTEIN IIb-IIIa DEFICIENCY, Glanzmann's thrombasthenia 
A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and… 
National Institutes of Health

Related topics

Related topics

21 relations
Autosomal recessive inheritanceBernard-Soulier SyndromeEpistaxisGastrointestinal Hemorrhage

Broader (1)

Blood Platelet Disorders

Narrower (3)

Glanzmann Thrombasthenia, Autosomal DominantGlanzmann Thrombasthenia, Type ASchlegelberger Grote syndrome

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Critical Role of β3 Integrin in Experimental Postmenopausal Osteoporosis
We show that mice lacking β3 integrin are protected from OVX‐induced bone loss. Using a lentiviral‐based strategy to express β3… 
Highly Cited
2004
Highly Cited
2004
Release of soluble CD40 ligand after platelet activation: studies on the solubilization phase.
Highly Cited
2003
Highly Cited
2003
Increased local procoagulant action: a mechanism contributing to the favorable hemostatic effect of recombinant FVIIa in PLT disorders
BACKGROUND: Recombinant FVIIa (rFVIIa) has been shown to improve hemostasis in patients with thrombocytopenia and to prevent or… 
Highly Cited
1991
Highly Cited
1991
Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate.
Highly Cited
1986
Highly Cited
1986
Acquired thrombasthenia due to GPIIb/IIIa-specific platelet autoantibodies.
An otherwise healthy woman developed a hemorrhagic diathesis with fluctuating clinical symptoms and laboratory findings, but… 
Highly Cited
1983
Highly Cited
1983
Characteristics of platelet aggregation induced by the monoclonal antibody ALB6 (acute lymphoblastic leukemia antigen p 24)
Highly Cited
1980
Highly Cited
1980
Binding of radioiodinated human von Willebrand factor to Bernard-Soulier, thrombasthenic and von Willebrand's disease platelets.
Highly Cited
1977
Highly Cited
1977
Thromboxane Synthesis and the Platelet Release Reaction in Bernard‐Soulier Syndrome, Thrombasthenia Glanzmann and Hermansky‐Pudlak Syndrome
Thromboxane (TX) synthesis was investigated in some characterized platelet disorders and correlated with release of ADP or [14C… 
Highly Cited
1974
Highly Cited
1974
Factor-VIII-related antigen in platelets.
Highly Cited
1972
Highly Cited
1972
PLASMA PROTEIN REQUIREMENTS FOR HUMAN PLATELET AGGREGATION
1. Three cationic proteins–fibrinogen, Hageman factor, and gamma globulin‐are all capable of restoring aggregation capability of… 
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