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Thiothixene

Known as: Thiothixine, Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)- 
A thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic… 
National Institutes of Health

Related topics

Related topics

23 relations
Adrenergic alpha-Antagonists [MoA]Blood Coagulation DisordersComatoseDrug Allergy

Broader (6)

Antipsychotic AgentsDopamine AntagonistsPhenazinesTranquilizing Agents

Narrower (3)

NavaneP-4657 BThiothixene hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Determination of thioxanthenes in plasma at therapeutic concentrations.
A method for measuring thioxanthenes at therapeutic levels in plasma, based on the measurement of the fluorescence of the… 
2004
2004
Correlation of thiothixene serum levels and age
Two experiments are reported in which acute single test dose levels of thiothixene (Navane) were correlated with age. In the… 
1994
1994
Seizures and clozapine dosing schedule.
1987
1987
Comprehensive high-performance liquid chromatographic methodology for the determination of thiothixene in bulk drug, finished product, and dissolution testing samples.
An HPLC methodology is described which enables the quantitation of thiothixene (N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl… 
Review
1985
Review
1985
Blood levels of neuroleptics: state of the art.
Difficulties in developing techniques to measure plasma levels of neuroleptic drugs have included the presence of metabolites, as… 
1983
1983
Correlation of initial thiothixene serum levels and clinical response. Comparison of fluorometric, gas chromatographic, and RBC assays.
A series of three experiments addressed major problems concerning the use of serum levels as predictors of clinical response to… 
1982
1982
Separation and quantitation of cis- and trans-thiothixene in human plasma by high-performance liquid chromatography.
A high-performance liquid chromatographic procedure is described for the separation of cis and trans isomers of thiothixene, a… 
1976
1976
Successful use of thiothixene in two cases of pathological jealousy.
Two cases of pathological jealousy are presented and their successful treatment with thiothixene is discussed. Evaluation of the… 
Review
1973
Review
1973
The dual action of thiothixene.
Dual action hypotheses have suggested that antipsychotic compounds may show a stimulating effect at low doses and an… 
1967
1967
Clinical trial of navane (THIOTHIXENE) in schizophrenia.