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Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
Sesamol seems to be an almost equally potent chemopreventive agent in the promotion stage of cancer development employing the in vitro Epstein-Barr virus early antigen activation assay induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines.
- G. Kapadia, M. Azuine, G. S. Rao, Takanari Arai, A. Iida, H. Tokuda
- BiologyAnti-cancer agents in medicinal chemistry
- 28 February 2011
The results suggest that betanin, the major betacyanin constituent, may play an important role in the cytotoxicity exhibited by the red beetroot extract.
Protective single/combined treatment with betel leaf and turmeric against methyl (acetoxymethyl) nitrosamine‐induced hamster oral carcinogenesis
The study suggests that BLE could be developed as a potential chemopreventive agent for human oral cancer.
Chemopreventive efficacy of a betel leaf extract against benzo[a]pyrene-induced forestomach tumors in mice.
Chemopreventive efficacy of betel leaf extract and its constituents on 7,12-dimethylbenz(a)anthracene induced carcinogenesis and their effect on drug detoxification system in mouse skin.
Intraperitoneal injection of betal leaf constituents showed a significant effect on both glutathione and glutathion S-transferase levels in the Swiss mouse skin.
Protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as Benzo[a]pyrene-induced genotoxicity and carcinogenicity
Data indicate that the protection against genomic damage by turmeric extract and its components tested could be necessary for some aspects of its cancer chemoprevention.
Aminonaphthoquinones--a novel class of compounds with potent antimalarial activity against Plasmodium falciparum.
- G. Kapadia, M. Azuine, V. Balasubramanian, R. Sridhar
- Chemistry, MedicinePharmacological research
- 1 April 2001
Among these compounds, 2-amino-3-chloro-1,4-naphthoquinone is the most potent and is more potent than chloroquine against Plasmodium falciparum, and the 4-aminos-1-2-napthoquone analog showed promising antimalarial activity in the bioassay.
Inhibitory effect of herbal remedies on 12-O-tetradecanoylphorbol-13-acetate-promoted Epstein-Barr virus early antigen activation.
Herbal remedies tested inhibited the EBV-EA in Raji cells exposed to the tumor promoter TPA by more than 90% and the activities of 16 new medicinal plants as potential cancer chemopreventive agents are reported for the first time.