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An antitumor promoter from Moringa oleifera Lam.
TLDR
Niazimicin was further subjected to in vivo test and found to have potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as initiator and TPA as tumor promoter. Expand
Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects.
TLDR
Among the compounds tested, seven compounds on TPA-induced inflammation, and six compounds on EBV-EA activation, exhibited potent inhibitory effects. Expand
Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects
TLDR
Eight triterpene acids isolated from ethanol extracts of the leaves of red and green perilla exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter. Expand
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
TLDR
Sesamol seems to be an almost equally potent chemopreventive agent in the promotion stage of cancer development employing the in vitro Epstein-Barr virus early antigen activation assay induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA). Expand
Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri.
TLDR
Upon evaluation of 17 compounds, 1-14 and 16-18, and compound 15, semi-synthesized from 14 by acetylation, for their inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, all of the compounds exhibited marked anti-inflammatory activity with a 50% inhibitory dose (ID(50) of 0.05-0.49 mg/ear. Expand
Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers.
TLDR
Two triterpene glycosides exhibited their most potent cytotoxic effects against colon cancer, leukemia, and melanoma cells against human cancer cell lines in vitro in the NCI Developmental Therapeutics Program. Expand
Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (Noni).
TLDR
Upon evaluation of six compounds for inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, four saccharide fatty acid esters exhibited potent anti-inflammatory activity, with ID50 values of 0.46-0.79 mg per ear. Expand
Production of bioactive triterpenes by Eriobotrya japonica calli.
TLDR
All of the triterpenes isolated from the callus tissues showed an inhibitory effect comparable to (-)-epigallocatechin gallate of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Expand
Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat.
TLDR
The biological activities of triterpene acetate and cinnamate esters, together with the exceptionally high levels of these triterpenes in shea fat, indicate that shea nuts and sheafat constitute a significant source of anti-inflammatory and anti-tumor promoting compounds. Expand
Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
TLDR
The most abundant triterpene, inotodiol, was investigated for the inhibitory effect in a two-stage carcinogenesis test on mouse skin using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter, and was found to exhibit the potent anti-tumor promoting activity in the in vivo carcinogenic test. Expand
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