Thiazolidinediones

Known as: glitazone, thiazolidinedione, Glitazones 
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The liver constitutes a key organ in systemic metabolism, contributing substantially to the development of insulin resistance and… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Thiazolidinediones may adversely affect the skeleton owing to decreased bone formation and accelerated bone loss… (More)
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Highly Cited
2005
Highly Cited
2005
Thiazolidinediones (TZDs) are widely used to treat type 2 diabetes mellitus; however, their use is complicated by systemic fluid… (More)
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Highly Cited
2004
Highly Cited
2004
Adiponectin is an adipocyte-specific secretory protein that circulates in serum as a hexamer of relatively low molecular weight… (More)
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Highly Cited
2002
Highly Cited
2002
The insulin-sensitizing effects of thiazolidinediones are thought to be mediated through peroxisome proliferator-activated… (More)
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Review
2002
Review
2002
Several cardiovascular risk factors (dyslipidaemia, hypertension, glucose intolerance, hypercoagulability, obesity… (More)
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Review
2001
Review
2001
The thiazolidinediones are a new class of compounds for treatment of type 2 diabetes mellitus. The efficacy of these drugs in… (More)
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Highly Cited
1998
Highly Cited
1998
The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a member of the nuclear receptor superfamily of ligand-dependent… (More)
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Review
1996
Review
1996
Insulin resistance, characterized by reduced responsiveness to normal circulating concentrations of insulin, is a common feature… (More)
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Highly Cited
1995
Highly Cited
1995
Thiazolidinedione derivatives are antidiabetic agents that increase the insulin sensitivity of target tissues in animal models of… (More)
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