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Thiazolidinediones

Known as: glitazone, thiazolidinedione, Glitazones 
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome… 
National Institutes of Health

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2,4-thiazolidinedioneAD 5075AL 321BLX 1002
In BloodPioglitazone hydrochlorideRosiglitazone maleateThiazolidinedione [EPC]

Papers overview

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Review
2009
Review
2009
Pleiotropic effects of thiazolidinediones on traditional and non‐traditional atherosclerotic risk factors
Background:  The thiazolidinediones pioglitazone and rosiglitazone have established efficacy in improving insulin sensitivity… 
2009
2009
Thiazolidinediones as Therapy for Endometriosis: A Case Series
Background: Current medical therapies for endometriosis result in delayed conception and have not been shown to provide any… 
2008
2008
New use of rosiglitazone decreased following publication of a meta‐analysis suggesting harm
Aims  It is uncertain whether meta‐analyses lead to changes in prescribing practices. We studied trends in the prescribing of… 
2006
2006
Trends in the use of oral antidiabetic drugs by outpatients in Taiwan: 1997–2003
Objective:  To define the prescribing patterns of oral antidiabetic drugs (OADs) in Taiwan over a 7‐year period (1997–2003) and… 
2006
2006
Thiazolidinediones for nonalcoholic steatohepatitis--promising but not ready for prime time.
Mostly unrecognized before 1980, nonalcoholic fatty liver disease now affects all fields of clinical medicine and is the most… 
2005
2005
Starting insulin therapy in type 2 diabetic patients: does it really matter how?
Type 2 diabetic patients failing oral antidiabetes medications need insulin. If used appropriately and with patient cooperation… 
Review
2004
Review
2004
Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases.
Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the nuclear receptor superfamily and… 
Highly Cited
2002
Highly Cited
2002
Severe Cholestatic Hepatitis Caused by Thiazolidinediones: Risks Associated with Substituting Rosiglitazone for Troglitazone
Troglitazone maleate (Rezulin) has been associated with severe hepatotoxicity, which led to its withdrawal from the U.S. market… 
Highly Cited
1997
Highly Cited
1997
Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y
1 The thiazolidinedione BRL 49653 (rosiglitazone) induces hyperphagia and weight gain in obese, insulin‐resistant fatty Zucker… 
Highly Cited
1992
Highly Cited
1992
Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents.
In the course of further chemical modification of the novel antidiabetic pioglitazone (AD-4833, U-72,107), a series of 5-[4-(2… 
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