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Thiazolidinediones

Known as: glitazone, thiazolidinedione, Glitazones 
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome… 
National Institutes of Health

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Narrower (29)

2,4-thiazolidinedioneAD 5075AL 321BLX 1002
In BloodPioglitazone hydrochlorideRosiglitazone maleateThiazolidinedione [EPC]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Visfatin expression is hormonally regulated by metabolic and sex hormones in 3T3‐L1 pre‐adipocytes and adipocytes
Aim:  The novel adipokine visfatin has ‘insulin‐mimicking’ effects and is increased in models of diet‐induced obesity, but… 
Highly Cited
2007
Highly Cited
2007
Selective modulation of promoter recruitment and transcriptional activity of PPARgamma.
Highly Cited
2005
Highly Cited
2005
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid and Related Compounds Inhibit Growth of Colon Cancer Cells through Peroxisome Proliferator-Activated Receptor γ-Dependent and -Independent Pathways
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) and the corresponding methyl (CDDO-Me) and imidazole (CDDO-Im) esters induce… 
Highly Cited
2004
Highly Cited
2004
Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry.
Review
2004
Review
2004
CD40 Ligand: A Novel Target in the Fight against Cardiovascular Disease
OBJECTIVE: To discuss the role of CD40 ligand (CD40L) in atherosclerosis and acute coronary syndromes (ACS), as well as describe… 
Review
2003
Review
2003
Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus.
Glucagon-like peptide-1-(7-36)-amide (GLP-1) is a potent blood glucose-lowering hormone now under investigation for use as a… 
Highly Cited
2003
Highly Cited
2003
Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.
Rosiglitazone and pioglitazone are thiazolidinediones used for treatment of noninsulin-dependent diabetes mellitus. These… 
Highly Cited
2002
Highly Cited
2002
A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while…
A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-alpha/gamma agonist, LY465608, was designed… 
Review
2001
Review
2001
Insulin-lowering drugs in polycystic ovary syndrome.
Highly Cited
1999
Highly Cited
1999
The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats.
Human obesity is associated with insulin resistance, hyperinsulinemia, and a predisposition to hypertension and vascular disease… 
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