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Thiazolidinediones

Known as: glitazone, thiazolidinedione, Glitazones 
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome… 
National Institutes of Health

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2,4-thiazolidinedioneAD 5075AL 321BLX 1002
In BloodPioglitazone hydrochlorideRosiglitazone maleateThiazolidinedione [EPC]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
Highly Cited
2011
Highly Cited
2011
Brain PPARγ Promotes Obesity and is Required for the Insulin–Sensitizing Effect of Thiazolidinediones
In adipose tissue, muscle, liver and macrophages, signaling by the nuclear receptor peroxisome proliferator–activated receptor… 
Highly Cited
2008
Highly Cited
2008
Use of thiazolidinediones and fracture risk.
BACKGROUND Thiazolidinediones may adversely affect the skeleton owing to decreased bone formation and accelerated bone loss… 
Highly Cited
2004
Highly Cited
2004
A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors.
BACKGROUND In patients with type 2 diabetes mellitus, all therapeutic options should be evaluated for their effect on… 
Highly Cited
2003
Highly Cited
2003
Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells.
The hypocholesterolemic and anti-atherosclerotic mechanism by which soy may exert a beneficial effect remains unclear. Peroxisome… 
Highly Cited
2002
Highly Cited
2002
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
BACKGROUND & AIMS The ligand-dependent transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) is… 
Highly Cited
2001
Highly Cited
2001
PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is highly expressed in lipid-accumulating macrophages of the coronary… 
Review
1999
Review
1999
Thiazolidinediones: a new class of antidiabetic drugs
Thiazolidinediones (TZDs) are a new class of oral antidiabetic agents. They selectively enhance or partially mimic certain… 
Highly Cited
1999
Highly Cited
1999
An Essential Regulator of Adipogenesis and Modulator of Fat Cell Function: PPARγ
Review
1996
Review
1996
Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology.
Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors that belong to the steroid/thyroid… 
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