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Rosiglitazone maleate

Known as: (+/-)-5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, ( Z )-2-Butenedioate (1:1), maleate rosiglitazone 
The maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (2)

AvandametAvandia

Broader (1)

BRL 49653
CYP2C9 protein, humanDiabetes Mellitus, Non-Insulin-DependentDrug AllergyLiver diseases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.
Review
2008
Review
2008
Energy restriction enhances therapeutic efficacy of the PPARγ agonist, rosiglitazone, through regulation of visceral fat gene expression
Aim:  Consumption of a palatable diet can induce hyperphagia, leading to weight gain (dietary obesity) and insulin resistance in… 
2008
2008
Late-Onset Rosiglitazone-Associated Acute Liver Failure in a Patient with Hodgkin's Lymphoma
Objective: To report a case of rosiglilazone-associated hepatotoxicity in a patient with Hodgkin's lymphoma. Case Summary: A 52… 
2007
2007
A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy and tolerability of combination therapy with rosiglitazone and sulfonylurea in African…
2006
2006
Perspective on a pathogenesis and treatment of Alzheimer’s disease
2005
2005
Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving protease inhibitor containing HAART.
AIMS Insulin resistance may be the primary event in the protease inhibitor-associated metabolic syndrome. Treatment with insulin… 
2005
2005
Improvement of glucose tolerance in Zucker diabetic fatty rats by long‐term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone
Aim:  The aim of this study was to investigate the effect of long‐term treatment with the dipeptidyl peptidase inhibitor P32/98… 
Review
2004
Review
2004
Rosiglitazone maleate/metformin hydrochloride: a new formulation therapy for type 2 diabetes.
Many patients with type 2 diabetes require treatment with more than one antihyperglycemic drug to achieve optimal glycemic… 
Highly Cited
2002
Highly Cited
2002
Severe Cholestatic Hepatitis Caused by Thiazolidinediones: Risks Associated with Substituting Rosiglitazone for Troglitazone
Troglitazone maleate (Rezulin) has been associated with severe hepatotoxicity, which led to its withdrawal from the U.S. market… 
Highly Cited
1999
Highly Cited
1999
The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats.
Human obesity is associated with insulin resistance, hyperinsulinemia, and a predisposition to hypertension and vascular disease… 
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