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A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
- L. Prokunina-Olsson, B. Muchmore, +21 authors T. O'Brien
- Biology, Medicine
- Nature Genetics
- 1 February 2013
Chronic infection with hepatitis C virus (HCV) is a common cause of liver cirrhosis and cancer. We performed RNA sequencing in primary human hepatocytes activated with synthetic double-stranded RNA… Expand
ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
- N. Chalasani, P. Hayashi, H. Bonkovsky, V. Navarro, William M. Lee, R. Fontana
- The American Journal of Gastroenterology
- 1 July 2014
Idiosyncratic drug-induced liver injury (DILI) is a rare adverse drug reaction and it can lead to jaundice, liver failure, or even death. Antimicrobials and herbal and dietary supplements are among… Expand
Recommendations for the Diagnosis and Treatment of the Acute Porphyrias
Key Summary Points Early Diagnosis of Acute Porphyria Consider in all adults with unexplained symptoms seen in acute porphyrias (Table 2); certain clinical features are suggestive: women of… Expand
Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment.
- M. Shiffman, A. D. Di Bisceglie, +11 authors J. Everhart
- Medicine, Chemistry
- 1 April 2004
BACKGROUND & AIMS The most effective therapy currently available for treatment of chronic hepatitis C virus (HCV) is the combination of peginterferon and ribavirin. This study evaluated the… Expand
Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States.
BACKGROUND & AIMS Idiosyncratic drug-induced liver injury (DILI) is among the most common causes of acute liver failure in the United States, accounting for approximately 13% of cases. A prospective… Expand
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.
BACKGROUND & AIMS The Drug-Induced Liver Injury Network is conducting a prospective study of patients with DILI in the United States. We present characteristics and subgroup analyses from the first… Expand
Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
Sphingosine 1-phosphate (S1P), an abundant lipid mediator in plasma, regulates vascular and immune cells by activating S1P receptors. In this report, we investigated the mechanisms by which high… Expand
Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: Results of the HALT‐C cohort
Knowledge of the presence of cirrhosis is important for the management of patients with chronic hepatitis C (CHC). Most models for predicting cirrhosis were derived from small numbers of patients and… Expand
MicroRNA‐196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins
Hepatitis C virus (HCV) directly induces oxidative stress and liver injury. Bach1, a basic leucine zipper mammalian transcriptional repressor, negatively regulates heme oxygenase 1 (HMOX1), a key… Expand
Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis.
BACKGROUND/AIMS Non-alcoholic steatohepatitis (NASH) is increasingly recognized, and its pathogenesis is believed to involve increased oxidative stress. Elevated levels of serum ferritin and positive… Expand