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- Publications
- Influence
A parametric analysis of olanzapine-induced weight gain in female rats
- G. Cooper, L. Pickavance, John P H Wilding, J. C. Halford, A. Goudie
- Medicine
- Psychopharmacology
- 19 March 2005
RationaleSome novel antipsychotics, including olanzapine, induce weight gain and metabolic abnormalities, which represent the major adverse effects of these drugs. However, the mechanism(s) involved… Expand
Effects of olanzapine in male rats: enhanced adiposity in the absence of hyperphagia, weight gain or metabolic abnormalities
- G. Cooper, L. Pickavance, John P H Wilding, J. A. Harrold, J. Halford, A. Goudie
- Biology, Medicine
- Journal of psychopharmacology
- 1 June 2007
Many of olanzapine's (OLZ) actions in humans related to weight regulation can be modelled in female rats (Cooper et al., 2005). Such effects include weight gain, hyperphagia, enhanced visceral… Expand
Therapeutic index for rosiglitazone in dietary obese rats: separation of efficacy and haemodilution
- L. Pickavance, M. Tadayyon, P. Widdowson, R. Buckingham, John P H Wilding
- Medicine
- British journal of pharmacology
- 1 December 1999
The blood glucose‐lowering efficacy of rosiglitazone (RSG) and the mechanisms of associated weight gain were determined in dietary obese rats (DIOs). DIO and chow‐fed rats received RSG 0.3–30 mg kg−1… Expand
Dietary obesity in the rat induces endothelial dysfunction without causing insulin resistance: a possible role for triacylglycerols.
- E. Naderali, M. Brown, L. Pickavance, John P H Wilding, P. Doyle, G. Williams
- Medicine
- Clinical science
- 1 November 2001
Impaired arterial vasorelaxation, due primarily to endothelial dysfunction, is associated with obesity. To clarify the relationship with insulin resistance and other metabolic disturbances, we… Expand
Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY.
- C. Bing, H. Frankish, +4 authors G. Williams
- Biology, Medicine
- American journal of physiology. Regulatory…
- 1998
Chronic cold exposure stimulates sympathetically driven thermogenesis in brown adipose tissue (BAT), resulting in fat mobilization, weight loss, and compensatory hyperphagia. Hypothalamic… Expand
Interactions Between Leptin and Hypothalamic Neuropeptide Y Neurons in the Control of Food Intake and Energy Homeostasis in the Rat
- Q. Wang, C. Bing, +15 authors G. Williams
- Biology, Medicine
- Diabetes
- 1 March 1997
Leptin acts on the brain to inhibit feeding, increase thermogenesis, and decrease body weight. Neuropeptide Y (NPY)-ergic neurons of the hypothalamic arcuate nucleus (ARC) that project to the… Expand
The serotonergic agent fluoxetine reduces neuropeptide y levels and neuropeptide y secretion in the hypothalamus of lean and obese rats
- S. Dryden, H. Frankish, Q. Wang, L. Pickavance, G. Williams
- Biology, Medicine
- Neuroscience
- 1 May 1996
Evidence suggests that serotonin and neuropeptide Y neurons in the hypothalamus, which respectively inhibit and stimulate food intake, may interact to control energy homoeostasis. We therefore… Expand
Murine PGK‐1 promoter drives widespread but not uniform expression in transgenic mice
- M. McBurney, W. A. Staines, K. Boekelheide, D. Parry, K. Jardine, L. Pickavance
- Biology, Medicine
- Developmental dynamics : an official publication…
- 1 August 1994
Pgk‐1 is an X‐linked gene encoding 3‐phosphoglycerate kinase, an enzyme necessary in every cell for glycolysis. The regulatory sequences of the Pgk‐1 gene were used to drive the E. coli lacZ reporter… Expand
Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY.
- C. Bing, H. Frankish, +4 authors G. Williams
- Biology, Medicine
- The American journal of physiology
- 1998
Chronic cold exposure stimulates sympathetically driven thermogenesis in brown adipose tissue (BAT), resulting in fat mobilization, weight loss, and compensatory hyperphagia. Hypothalamic… Expand
The dual PPARalpha/gamma agonist, ragaglitazar, improves insulin sensitivity and metabolic profile equally with pioglitazone in diabetic and dietary obese ZDF rats.
- L. Pickavance, C. L. Brand, K. Wassermann, John P H Wilding
- Medicine
- British journal of pharmacology
- 2005
In 6- and 10-week-old obesity-prone (fa/fa) Zucker diabetic fatty (ZDF) rats, effects of prevention and intervention therapies, respectively, were compared between PPARalpha/gamma agonist,… Expand