Tertiary Lymphoid Structures

Known as: Ectopic Lymphoid Organs, Ectopic Lymphoid Formations, Tertiary Lymphoid Structures [Disease/Finding] 
Aggregates of immune cells formed near the sites of chronically inflamed, infected, or tumorous tissues.
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer.
RATIONALE It is now well established that immune responses can take place outside of primary and secondary lymphoid organs. We… (More)
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Review
2013
Review
2013
Characteristics of tertiary lymphoid structures in primary cancers
Tumors are sustained by complex networks of interactions between malignant cells, stromal cells and tumor-infiltrating immune… (More)
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Highly Cited
2009
Highly Cited
2009
Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus–infected mice
Tertiary lymphoid organs (TLOs) are organized aggregates of B and T cells formed in postembryonic life in response to chronic… (More)
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Highly Cited
2006
Highly Cited
2006
Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid.
Ectopic expression of CC chemokine ligand 21 (CCL21) in the thyroid leads to development of lymphoid structures that resemble… (More)
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Highly Cited
2004
Highly Cited
2004
Induction of secondary and tertiary lymphoid structures in the skin.
During embryogenesis a developmental program leading to the formation of lymph nodes and Peyer's patches is initiated. We now… (More)
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Highly Cited
2002
Highly Cited
2002
Stem cell properties of human dental pulp stem cells.
In this study, we characterized the self-renewal capability, multi-lineage differentiation capacity, and clonogenic efficiency of… (More)
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Highly Cited
2001
Highly Cited
2001
Lymphoid neogenesis in rheumatoid synovitis.
In rheumatoid arthritis (RA), tissue-infiltrating lymphocytes can be arranged in sophisticated organizations that resemble… (More)
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Highly Cited
2000
Highly Cited
2000
Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
C57BL/6 mice genetically deficient in interleukin 15 (IL-15(-/-) mice) were generated by gene targeting. IL-15(-/-) mice… (More)
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Highly Cited
1998
Highly Cited
1998
Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.
BACKGROUND Atrial fibrillation, the most common sustained cardiac arrhythmia and a major cause of stroke, results from… (More)
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Review
1991
Review
1991
p53 mutations in human cancers.
Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer… (More)
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