• Publications
  • Influence
Electric current flow in excitable cells
Conduction of Electrical Current to and Through the Human February 6th, 2017 PART A BASICS OF ELECTRICITY AND HOW IT INTERACTS WITH THE HUMAN BODY Electric shock is defined as a sudden violentExpand
A model of cardiac electrical activity incorporating ionic pumps and concentration changes.
The model takes account of extensive developments in experimental work since the formulation of the M.N. Noble equations, and successfully account for all the properties formerly attributed to i $\_{K2}$ , as well as giving more complete descriptions of i $\_K$ and i $\-K$ . Expand
Reconstruction of the electrical activity of cardiac Purkinje fibres.
1. The electrical activity of Cardiac Purkinje fibres was reconstructed using a mathematical model of the membrane current. The individual components of ionic curent were described by equations whichExpand
Cardiac Action and Pacemaker Potentials based on the Hodgkin-Huxley Equations
  • D. Noble
  • Chemistry, Medicine
  • Nature
  • 5 November 1960
The equations describing the nerve action potential were formulated by Hodgkin and Huxley and it has been shown that the long action potentials induced by tetraethylammonium ions in squid nerve may also be reproduced. Expand
Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms
The model reconstructs extracellular calcium transients and typical action-potential configuration changes during steady-state and non-steady-state stimulation from the mechanisms directly involved in trans-sarcolemmal calcium movements. Expand
The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres
It is concluded that virtually all of the slow outward current in Purkinje fibres is carried by potassium ions. Expand
A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations
  • D. Noble, S. Noble
  • Chemistry, Medicine
  • Proceedings of the Royal Society of London…
  • 22 September 1984
DiFrancesco & Noble’s (1984) equations have been modified to apply to the mammalian sino-atrial node and successfully reproduce action potential and pacemaker activity in the node. Expand
Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres
The results show that in this range slow outward current changes occur which are quite distinct from the potassium current activated in the pace‐maker range of potentials. Expand
The surprising heart: a review of recent progress in cardiac electrophysiology.
  • D. Noble
  • Medicine
  • The Journal of physiology
  • 1 August 1984