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Tenofovir

Known as: Anhydrous tenofovir, (R)-9-(2-phosphonomethoxypropyl)adenine, Tenofovir (anh.) 
An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and… 
National Institutes of Health

Related topics

Related topics

28 relations
Acquired Immunodeficiency SyndromeDrug AllergyHIV InfectionsHepatitis B

Broader (3)

Anti-HIV AgentsAntiviral AgentsReverse Transcriptase Inhibitors

Narrower (3)

Vireademtricitabine / tenofovir alafenamidetenofovir disoproxil

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Association of tenofovir exposure with kidney disease risk in HIV infection
Objective:Despite widespread HAART use, HIV disease remains associated with increased risk of kidney disease. Whether tenofovir… 
Highly Cited
2011
Highly Cited
2011
Prevention of mother-to-child transmission of HIV and the health-related Millennium Development Goals: time for a public health approach
Highly Cited
2010
Highly Cited
2010
Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities.
Tenofovir, a widely prescribed antiretroviral medication for treatment of HIV-1 infection, is infrequently associated with renal… 
Highly Cited
2009
Highly Cited
2009
Achieving Unity of Effort: Leveraging Interagency Cooperation Between the Department of Defense (DOD) and the United States Agency for International Development (USAID)
Abstract : America's wars cannot be won simply by applying lethal effects. The U.S. military can defeat any adversary using… 
Highly Cited
2009
Highly Cited
2009
Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer.
Prostate-specific membrane antigen (PSMA) is expressed in normal human prostate epithelium and is highly up-regulated in prostate… 
Highly Cited
2007
Highly Cited
2007
Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir
Acyclic nucleotide phosphonates (adefovir, cidofovir, and tenofovir) are eliminated predominantly into the urine, and renal… 
Highly Cited
2007
Highly Cited
2007
Renal Transport of Adefovir, Cidofovir, and Tenofovir by SLC22A Family Members (hOAT1, hOAT3, and hOCT2)
PurposeThe nephrotoxicity of the nucleotide antivirals adefovir, cidofovir and tenofovir is considered to depend on the renal… 
Highly Cited
2006
Highly Cited
2006
Mechanism of Active Renal Tubular Efflux of Tenofovir
ABSTRACT Tenofovir (TFV) undergoes renal elimination by a combination of glomerular filtration and active tubular secretion… 
Highly Cited
2003
Highly Cited
2003
Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus.
We report 3 cases of renal toxicity associated with use of the antiviral agent tenofovir. Renal failure, proximal tubular… 
Highly Cited
2002
Highly Cited
2002
Fanconi syndrome and renal failure induced by tenofovir: a first case report.
Although nephrotoxicity of cidofovir and adefovir is well established, no renal side effects have been observed yet with… 
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