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Telomerase

Known as: Telomerase Reverse Transcriptase, Reverse Transcriptase, Telomerase, Telomerase [Chemical/Ingredient] 
An enzyme in cells that helps keep them alive by adding DNA to telomeres (the ends of chromosomes). Each time a cell divides, the telomeres lose a… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Maintenance of chromosomal telomere length is a hallmark of cancer cells and a prerequisite for stemness. In 85–90% of all human… Expand
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Highly Cited
2007
Highly Cited
2007
Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown… Expand
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Highly Cited
1999
Highly Cited
1999
Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes… Expand
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Highly Cited
1998
Highly Cited
1998
Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative… Expand
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Highly Cited
1998
Highly Cited
1998
We have investigated the role of the enzyme telomerase in highly proliferative organs in successive generations of mice lacking… Expand
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Highly Cited
1997
Highly Cited
1997
Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal human somatic cells but is reactivated… Expand
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Highly Cited
1997
Highly Cited
1997
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Telomerase RNA… Expand
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Highly Cited
1989
Highly Cited
1989
The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added… Expand
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Highly Cited
1985
Highly Cited
1985
We have found a novel activity in Tetrahymena cell free extracts that adds tandem TTGGGG repeats onto synthetic telomere primers… Expand
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