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Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion
The gene for spinocerebellar ataxia 7 (SCA7) has been mapped to chromosome 3p12–13. By positional cloning, we have identified a new gene of unknown function containing a CAG repeat that is expandedExpand
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Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.
The epidermal growth factor receptor (EGFR) is overexpressed in the majority of non-small cell lung cancers (NSCLC). EGFR tyrosine kinase inhibitors, such as gefitinib and erlotinib, produce 9% toExpand
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Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer.
Elevated tumor cyclooxygenase-2 (COX-2) expression is associated with tumor invasion, metastasis, and poor prognosis in non-small cell lung cancer (NSCLC). Here, we report that COX-2-dependentExpand
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The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER
Human cytomegalovirus uses an E3 ubiquitin ligase to divert MHC I molecules into the ER-associated degradation pathway for destruction.
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WNT7a induces E-cadherin in lung cancer cells.
E-cadherin loss in cancer is associated with de-differentiation, invasion, and metastasis. Drosophila DE-cadherin is regulated by Wnt/beta-catenin signaling, although this has not been demonstratedExpand
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Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B.
Loss of heterozygosity (LOH) involving 3p occurs in many carcinomas but is complicated by the identification of four distinct homozygous deletion regions. One putative target, 3p14.2, contains theExpand
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Molecular definition of a small amplification domain within 3q26 in tumors of cervix, ovary, and lung.
A common amplification target encompassing chromosome region 3q25 to q27 has been identified by comparative genomic hybridization analyses in tumors of the cervix, ovary, endometrium, lung, and headExpand
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Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin.
Loss of chromosome 3p is a critical event in the pathogenesis of lung cancer. Overlapping homozygous 3p21.3 deletions in lung cancer cell lines involving GNAI2 were characterized and found to involveExpand
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High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer.
PURPOSE E-cadherin (E-cad) and its associated intracellular molecules, catenins, are critical for intercellular epithelial adhesion and are often expressed in non-small-cell lung carcinomas (NSCLCs).Expand
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Homozygous deletions of human chromosome 3p in lung tumors.
Cytogenetic and loss of heterozygosity (LOH) studies have demonstrated that deletions of chromosome 3p occur at a high frequency in all forms of lung cancer. To clarify the role of 3p in lungExpand
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