Semantic Scholar uses AI to extract papers important to this topic.
The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity… Expand The NF-κB family of transcription factors has an essential role in inflammation and innate immunity. Furthermore, NF-κB is… Expand Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit the progression of preneoplastic… Expand The ATM protein kinase, mutations of which are associated with the human disease ataxia–telangiectasia, mediates responses to… Expand Maintenance of genome stability is essential for avoiding the passage to neoplasia. The DNA-damage response — a cornerstone of… Expand The function of the ATR (ataxia-telangiectasia mutated– and Rad3-related)–ATRIP (ATR-interacting protein) protein kinase complex… Expand A very early step in the response of mammalian cells to DNA double-strand breaks is the phosphorylation of histone H2AX at serine… Expand The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents. The… Expand A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) was identified by positional cloning… Expand Cell cycle checkpoints can enhance cell survival and limit mutagenic events following DNA damage. Primary murine fibroblasts… Expand