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Tacrolimus Binding Protein 1A

Known as: Macrophilin-12, FK506-Binding Protein 1, FKBP 12 
A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of calcium release channels. It is a peptidyl-prolyl… Expand
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Duchenne muscular dystrophy is characterized by progressive muscle weakness and early death resulting from dystrophin deficiency… Expand
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Highly Cited
2006
Highly Cited
2006
The 12 kDa FK506-binding protein (FKBP12) constitutively binds to the calcium release channel RyR1. Removal of FKBP12 using FK506… Expand
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Highly Cited
2001
Highly Cited
2001
The ryanodine receptor (RyR1)/calcium release channel on the sarcoplasmic reticulum of skeletal muscle is comprised of four 565… Expand
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Highly Cited
2001
Highly Cited
2001
Syncytia arising from the fusion of cells expressing a lymphotropic human immunodeficiency virus (HIV)-1–encoded envelope… Expand
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Highly Cited
1998
Highly Cited
1998
FKBP12, a cis–trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, is ubiquitouslyexpressed and… Expand
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Highly Cited
1997
Highly Cited
1997
FKBP12 was removed from ryanodine receptors (RyRs) by incubation of rabbit skeletal muscle terminal cisternae membranes with… Expand
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Highly Cited
1996
Highly Cited
1996
Rapamycin, a potent immunosuppressive agent, binds two proteins: the FK506-binding protein (FKBP12) and the FKBP-rapamycin… Expand
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Highly Cited
1996
Highly Cited
1996
The calcium release channels (CRC)/ryanodine receptors of skeletal (Sk) and cardiac (C) muscle sarcoplasmic reticulum (SR) are… Expand
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Highly Cited
1995
Highly Cited
1995
The immunosuppressant drug FK506 binds to the immunophilin protein FKBP12 and inhibits its prolyl isomerase activity… Expand
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Highly Cited
1993
Highly Cited
1993
The ryanodine receptor/calcium release channel (CRC) of rabbit skeletal muscle terminal cisternae (TC) of sarcoplasmic reticulum… Expand
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