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Tacrolimus Binding Protein 1A

Known as: Macrophilin-12, FK506-Binding Protein 1, FKBP 12 
A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of calcium release channels. It is a peptidyl-prolyl… 
National Institutes of Health

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FKBP1A protein, humanFKBP1A wt AlleleIn BloodProcess of secretion

Papers overview

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Review
2015
Review
2015
Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulation.
The 12- and 12.6-kDa FK506-binding proteins, FKBP12 (12-kDa FK506-binding protein) and FKBP12.6 (12.6-kDa FK506-binding protein… 
Highly Cited
2006
Highly Cited
2006
Structural characterization of the RyR1-FKBP12 interaction.
Highly Cited
2001
Highly Cited
2001
FKBP12 Binding Modulates Ryanodine Receptor Channel Gating*
The ryanodine receptor (RyR1)/calcium release channel on the sarcoplasmic reticulum of skeletal muscle is comprised of four 565… 
1999
1999
High Throughput Scintillation Proximity Assay for the Identification of FKBP-12 Ligands
A high throughput scintillation proximity assay (SPA) was developed to identify novel ligands of FKBP-12, an immunophilin with… 
Highly Cited
1998
Highly Cited
1998
Oral administration of a nonimmunosuppressant FKBP‐12 ligand speeds nerve regeneration
WE recently showed that s.c. injections of a nonimmunosuppressant FK506 binding protein-12 (FKBP-12) ligand (V-10,367… 
1998
1998
FKBP12 Modulates Gating of the Ryanodine Receptor/Calcium Release Channel a
ABSTRACT: Excitation‐contraction (EC) coupling in muscle requires the activation of intracellular calcium release channels (CRC… 
1997
1997
FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae
The peptidyl-prolyl isomerase FKBP12 was originally identified as the intracellular receptor for the immunosuppressive drugs… 
1995
1995
Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface.
1993
1993
The mammalian heat shock protein binding immunophilin (p59/HBI) is an ATP and GTP binding protein.
A protein of M(r) 59,000 (p59) was recently cloned and identified as a Heat shock protein Binding Immunophilin (p59/HBI). It… 
1992
1992
Solution structure of FK506 bound to FKBP‐12
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