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Altered microRNA expression in human heart disease.
MicroRNAs are recently discovered regulators of gene expression and are becoming increasingly recognized as important regulators of heart function. Genome-wide profiling of microRNAs in human heartExpand
Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating
Ryanodine receptor type 1 (RyR1) produces spatially and temporally defined Ca2+ signals in several cell types. How signals received in the cytoplasmic domain are transmitted to the ion gate and howExpand
Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor
EXCITATION-CONTRACTION coupling in skeletal muscle involves a voltage sensor in the plasma membrane which, in response to depolarization, causes an intracellular calcium-release channel to open. TheExpand
Timing of new black box warnings and withdrawals for prescription medications.
CONTEXT Recently approved drugs may be more likely to have unrecognized adverse drug reactions (ADRs) than established drugs, but no recent studies have examined how frequently postmarketingExpand
Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM
RyR1 is an intracellular calcium channel with a central role in muscle contraction. We obtained a three-dimensional reconstruction of the RyR1 in the closed state at a nominal resolution of ∼10 ÅExpand
Transmembrane Redox Sensor of Ryanodine Receptor Complex*
Inositol 1,4,5-trisphosphate receptors (IP3R) and ryanodine receptors (RyR) mediate the release of endoplasmic and sarcoplasmic reticulum (ER/SR) Ca2+stores and regulate Ca2+ entry throughExpand
Pharmacologic and Functional Characterization of Malignant Hyperthermia in the R163C RyR1 Knock-in Mouse
Background:Malignant hyperthermia is a pharmacogenetic disorder affecting humans, dogs, pigs, and horses. In the majority of human cases and all cases in animals, malignant hyperthermia has beenExpand
Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin‐1
Calsequestrin (CS), the major Ca2+‐binding protein in the sarcoplasmic reticulum (SR), is thought to play a dual role in excitation–contraction coupling: buffering free Ca2+ increasing SR capacity,Expand
Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray.
To obtain a genomic portrait of heart failure derived from end-stage dilated cardiomyopathy (DCM), we explored expression analysis using the CardioChip, a nonredundant 10,848-element humanExpand
Two Regions of the Ryanodine Receptor Involved in Coupling withl-Type Ca2+ Channels*
Ryanodine receptors (RyRs) are present in the endoplasmic reticulum of virtually every cell type and serve critical roles, including excitation-contraction (EC) coupling in muscle cells. In skeletalExpand