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TYRP1 protein, human

Known as: melanoma antigen gp75, human, brown locus protein, human, TYRP 
5,6-dihydroxyindole-2-carboxylic acid oxidase (537 aa, ~61 kDa) is encoded by the human TYRP1 gene. This protein plays a role in melanin biosynthesis… 
National Institutes of Health

Related topics

Related topics

13 relations
Enzyme GeneGlycoproteinsMelanogenesisMelanogenesis Pathway

Broader (3)

Membrane GlycoproteinsOxidoreductaseTyrosinase related protein-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Amyloid b-protein (Ab) assembly: Ab40 and Ab42 oligomerize through distinct pathways
Amyloid b-protein (Ab) is linked to neuronal injury and death in Alzheimer’s disease (AD). Of particular relevance for… 
2003
2003
The acclimative response of the main light-harvesting chlorophyll a/b-protein complex of photosystem II (LHCII) to elevated irradiances at the level of trimeric subunits.
Review
2001
Review
2001
Presenilin, Notch, and the genesis and treatment of Alzheimer's disease
Elucidation of the proteolytic processing of the amyloid β-protein precursor (APP) has revealed that one of the two proteases… 
Review
2001
Review
2001
Tyrp1 and oculocutaneous albinism type 3.
Tyrosinase-related protein 1 (Tyrp1) is a melanocyte-specific gene product involved in eumelanin synthesis. Mutations in the… 
Highly Cited
2000
Highly Cited
2000
Suppressor mutations that allow sindbis virus RNA polymerase to function with nonaromatic amino acids at the N-terminus: evidence for interaction between nsP1 and nsP4 in minus-strand RNA synthesis.
The alphavirus RNA polymerase, nsP4, invariably has a Tyr residue at the N-terminus. Previously we reported that the N-terminal… 
Highly Cited
1996
Highly Cited
1996
Functional Analysis of a p21WAF1,CIP1,SDI1 Mutant (Arg94 → Trp) Identified in a Human Breast Carcinoma
Human p21 (also known as WAF1, CIP1, or SDI1) is a dual inhibitor of cyclin dependent kinases (CDKs) and the replication factor… 
Highly Cited
1993
Highly Cited
1993
Subcellular distribution of tyrosinase and tyrosinase-related protein-1: implications for melanosomal biogenesis.
Are tyrosinase, encoded at the albino locus, and tyrosinase-related protein-1 (TRP-1), encoded at the brown locus, similarly… 
Highly Cited
1991
Highly Cited
1991
Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin.
Transcriptional activation by the HIV-1 Tat protein requires specific residues in the hexanucleotide loop and trinucleotide bulge… 
Highly Cited
1990
Highly Cited
1990
Sensitivity of tryptophan and related compounds to oxidation induced by lipid autoperoxidation. Application to human serum low- and high-density lipoproteins.
Highly Cited
1988
Highly Cited
1988
Determination of the aggregate size in detergent solution of the light-harvesting chlorophyll a/b-protein complex from chloroplast membranes.
The molecular mass of an oligomeric integral membrane protein, the light-harvesting chlorophyll a/b-protein complex from the… 
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