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One‐thousand‐and‐one substrates of protein kinase CK2?
  • F. Meggio, L. Pinna
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 March 2003
TLDR
An analysis of 308 sites phosphorylated by CK2 highlights the paramount relevance of negatively charged side chains that are (by far) predominant over any other residues at positions n+3 (the most crucial one), n+1, and n+2. Expand
Selectivity of 4,5,6,7‐tetrabromobenzotriazole, an ATP site‐directed inhibitor of protein kinase CK2 (‘casein kinase‐2’)
TLDR
Data show that TBB is a quite selective inhibitor of CK2, that can be used in cell‐based assays and also inhibits endogenous CK2 in cultured Jurkat cells. Expand
Inhibition of cyclin-dependent kinases by purine analogues.
TLDR
Through its unique selectivity olomoucine provides an anti-mitotic reagent that may preferentially inhibit certain steps of the cell cycle and inhibits the licensing factor, an essential replication factor ensuring that DNA is replicated only once in each cell cycle. Expand
Protein kinase CK2: a challenge to canons.
  • L. Pinna
  • Medicine, Biology
  • Journal of cell science
  • 15 October 2002
CK2 is an extremely conserved pleiotropic protein kinase with a growing list of more than 300 substrates, the majority of which are proteins implicated in signal transduction, gene expression andExpand
Casein kinase 2: an 'eminence grise' in cellular regulation?
  • L. Pinna
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 24 September 1990
Protein kinase CK2: a challenge to canons
  • L. Pinna
  • Biology, Medicine
  • Journal of Cell Science
  • 15 October 2002
TLDR
These unusual features of the CK2 holoenzyme are likely to be instrumental in the involvement of CK2 in a number of key biological functions, notably RNA synthesis, Wnt signaling, ubiquitination and cell survival. Expand
The Protein Kinase CK2 Facilitates Repair of Chromosomal DNA Single-Strand Breaks
TLDR
It is shown that CK2 phosphorylates the scaffold protein XRCC1 and thereby enables the assembly and activity of DNA single-strand break repair protein complexes in vitro and at sites of chromosome breakage. Expand
Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.
TLDR
These findings, in conjunction with similar data in the literature concerning two other CK2 protein substrates, suggest that CK2 may play a general anti-apoptotic role through the generation of phosphorylated sites conferring resistance to caspase cleavage. Expand
Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[boxs]
TLDR
The results show that (R)-roscovitine is rather selective for CDKs, in fact most kinases are not affected, but it binds an unexpected, non-protein kinase target, pyridoxal kinase, the enzyme responsible for phosphorylation and activation of vitamin B6. Expand
Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis.
TLDR
A direct correlation between high basal Lyn activity and defects in the induction of apoptosis in leukemic cells is suggested and a critical role for Lyn is supported in B-CLL pathogenesis and this tyrosine kinase is identified as a potential therapeutic target. Expand
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