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TV-1380

 
National Institutes of Health

Related topics

Related topics

4 relations
Albu-BChE

Broader (3)

AlbuminsButyrylcholinesteraseRecombinant Fusion Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Reengineering of Albumin-Fused Cocaine Hydrolase CocH1 (TV-1380) to Prolong Its Biological Half-Life
Therapeutic treatment of cocaine toxicity or addiction is a grand medical challenge. As a promising therapeutic strategy for… Expand
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2018
2018
TV-1380 attenuates cocaine-induced changes in cardiodynamic parameters in monkeys and reduces the formation of cocaethylene.
BACKGROUND TV-1380 is a rationally mutated, human BChE fused to human serum albumin that has high hydrolytic enzymatic activity… Expand
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2016
2016
Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence.
BACKGROUND TV-1380 (AlbuChE) is a novel recombinant fusion protein of mutated butyrylcholinesterase (BChE) that has increased… Expand
2016
2016
Benzoic acid is not the only important product of accelerated metabolism of cocaine
  • S. Curry, S. Coombs
  • Proceedings of the National Academy of Sciences
  • 2016
    • Corpus ID: 205279275
Xiabin Chen et al. (1) describe pioneering work with a modified drug-metabolizing enzyme, a butyrylcholinesterase (BChE) analog… Expand
2016
2016
Reply to Curry and Coombs: Benzoic acid is formed predominantly from the benzoyl ester hydrolysis in the presence of cocaine hydrolase
  • F. Zheng, C. Zhan
  • Proceedings of the National Academy of Sciences
  • 2016
    • Corpus ID: 29919957
As is well known, and also pointed out correctly by Curry and Coombs (1), cocaine has three metabolic pathways associated with… Expand
2016
2016
lacebo-controlled evaluation of a bioengineered , ocaine-metabolizing fusion protein , TV-1380 ( AlbuBChE ) , in the reatment of cocaine dependence
  • ossi Gilgun-Sherkia, Rom E. Eliazb, +7 authors Shwe Gyawc
  • 2016
    • Corpus ID: 145044520
Background: TV-1380 (AlbuChE) is a novel recombinant fusion protein of mutated butyrylcholinesterase (BChE) that has increased… Expand
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2015
2015
Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy…
Human plasma butyrylcholinesterase (BChE) contributes to cocaine metabolism and has been considered for use in treating cocaine… Expand
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