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TV-1380

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2015-2015
01220152015

Related topics

Related topics

4 relations
Albu-BChE

Broader (3)

AlbuminsButyrylcholinesteraseRecombinant Fusion Proteins

Related mentions per year

Related mentions per year

1938-2018
19401960198020002020
TV-1380
Albumins
Butyrylcholinesterase
Recombinant Fusion Proteins
Albu-BChE

Papers overview

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2016
2016
Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence.
BACKGROUND TV-1380 (AlbuChE) is a novel recombinant fusion protein of mutated butyrylcholinesterase (BChE) that has increased… (More)
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2016
2016
Reply to Curry and Coombs: Benzoic acid is formed predominantly from the benzoyl ester hydrolysis in the presence of cocaine hydrolase.
As is well known, and also pointed out correctly by Curry and Coombs (1), cocaine has three metabolic pathways associated with… (More)
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2016
2016
Benzoic acid is not the only important product of accelerated metabolism of cocaine.
Xiabin Chen et al. (1) describe pioneering work with a modified drug-metabolizing enzyme, a butyrylcholinesterase (BChE) analog… (More)
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2015
2015
Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy…
Human plasma butyrylcholinesterase (BChE) contributes to cocaine metabolism and has been considered for use in treating cocaine… (More)
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2015
2015
Assessment of Pharmacokinetic and Pharmacodynamic Interactions Between Albumin-Fused Mutated Butyrylcholinesterase and Intravenously Administered Cocaine in Recreational Cocaine Users.
UNLABELLED Cocaine dependence presents a major public health issue, and to date, no pharmacotherapies are approved for its… (More)
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