Benzoic acid is not the only important product of accelerated metabolism of cocaine

@article{Curry2016BenzoicAI,
  title={Benzoic acid is not the only important product of accelerated metabolism of cocaine},
  author={S. Curry and S. Coombs},
  journal={Proceedings of the National Academy of Sciences},
  year={2016},
  volume={113},
  pages={E2101 - E2101}
}
  • S. Curry, S. Coombs
  • Published 2016
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences
Xiabin Chen et al. (1) describe pioneering work with a modified drug-metabolizing enzyme, a butyrylcholinesterase (BChE) analog, intended to prolong BChE activity in humans, hoping that the result would be accelerated cocaine metabolism. This work is exciting to those involved in pharmacokinetic approaches to drug toxicity; such constructs promise to be the first drug-metabolizing enzymes used as therapeutic agents. The analog described (1) seems to be the third of its type; this analog is… Expand
Effects of ecgonine methyl ester on cognition in scopolamine-impaired and aged rats

References

SHOWING 1-7 OF 7 REFERENCES
Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase.
Long-acting cocaine hydrolase for addiction therapy
Therapeutic treatment for drug poisoning and addiction