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Disposition and pharmacodynamics of dichloroacetate (DCA) and oxalate following oral DCA doses
Healthy volunteers received intravenous and/or oral doses of sodium dichloroacetate (DCA) in various single and multiple dose regimens. A crossover bioavailability study proved abortive becauseExpand
Treatment of lactic acidosis with dichloroacetate.
We administered dichloroacetate, which prevents or reverses hyperlactatemia in animals and lowers plasma lactate levels in human beings, to 13 patients with lactic acidosis of various causes. All hadExpand
Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man.
1 Fluphenazine (1,2-ethanol 14C) was administered to seven human subjects as the dihydrochloride and as the enanthate and decanoate esters. 2 The subjects had previously been treated withExpand
Natural history and course of acquired lactic acidosis in adults
Abstract study objective: To determine the pathogenesis and clinical course of lactic acidosis in adults receiving standard medical care. design: Placebo arm of a 5-year prospective, randomized,Expand
Plasma concentrations and metabolic effects of intravenous sodium dichloroacetate
Eleven healthy subjects received five doses of intravenous sodium dichloroacetate (DCA) at 2‐hr intervals. Determinations of DCA in plasma and of lactate and glucose in blood were made at variousExpand
Pharmacokinetics and pharmacodynamics of acepromazine in horses.
A specific, sensitive, reverse-phase high-performance liquid chromatographic assay for acepromazine, with analytic sensitivity as low as 5 ng/ml of plasma, and electrochemical detection with anExpand
Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group.
STUDY OBJECTIVE To determine the pathogenesis and clinical course of lactic acidosis in adults receiving standard medical care. DESIGN Placebo arm of a 5-year prospective, randomized, blinded studyExpand
Amikacin sulfate in mares: pharmacokinetics and body fluid and endometrial concentrations after repeated intramuscular administration.
Six mares were given 5 IM injections (at 12-hour intervals between doses) of amikacin sulfate at a dosage of 7 mg/kg of body weight. Serum amikacin concentrations were measured serially throughoutExpand
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