Corpus ID: 145044520

lacebo-controlled evaluation of a bioengineered , ocaine-metabolizing fusion protein , TV-1380 ( AlbuBChE ) , in the reatment of cocaine dependence

@inproceedings{GilgunSherkia2016lacebocontrolledEO,
  title={lacebo-controlled evaluation of a bioengineered , ocaine-metabolizing fusion protein , TV-1380 ( AlbuBChE ) , in the reatment of cocaine dependence},
  author={ossi Gilgun-Sherkia and Rom E. Eliazb and David J. McCannc and Pippa S. Louped and Eli Eyale and A. Blatt and Orit Cohen-Barakg and Hussein Hallakh and Nora Chiangc and Shwe Gyawc},
  year={2016}
}
Background: TV-1380 (AlbuChE) is a novel recombinant fusion protein of mutated butyrylcholinesterase (BChE) that has increased catalytic efficiency for cocaine metabolism compared to wild-type BChE. Methods: Intra-muscular injections of TV-1380 (150 mg or 300 mg) or placebo were administered once weekly to participants (n = 66–69 per group) in a randomized, double-blind study to evaluate the ability of TV-1380 to facilitate abstinence in treatment-seeking, cocaine-dependent individuals. The… Expand

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