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TRRAP gene

Known as: TRANSFORMATION/TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN, Tra1, Transformation/Transcription Domain-Associated Protein Gene 
This gene is involved in DNA repair and regulation of mitosis.
National Institutes of Health

Related topics

Related topics

6 relations
Cell Cycle ControlHomo sapiensTRRAP protein, humanTranscriptional Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.
Highly Cited
2005
Highly Cited
2005
The Mammalian YL1 Protein Is a Shared Subunit of the TRRAP/TIP60 Histone Acetyltransferase and SRCAP Complexes*
The multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase (HAT) complex performs critical functions in a… 
Highly Cited
2004
Highly Cited
2004
A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.
Highly Cited
2003
Highly Cited
2003
c-Myc Transformation Domain Recruits the Human STAGA Complex and Requires TRRAP and GCN5 Acetylase Activity for Transcription Activation*
Deregulation of the c-Myc oncoprotein (Myc) is implicated in many types of cancer. Myc is a sequence-specific transcription… 
Highly Cited
2002
Highly Cited
2002
Nuclear receptor function requires a TFTC-type histone acetyl transferase complex.
Highly Cited
2002
Highly Cited
2002
BAF53 Forms Distinct Nuclear Complexes and Functions as a Critical c-Myc-Interacting Nuclear Cofactor for Oncogenic Transformation
ABSTRACT The c-Myc oncoprotein functions as a transcription factor that can transform normal cells into tumor cells, as well as… 
Highly Cited
2002
Highly Cited
2002
TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family Oncoproteins
ABSTRACT We demonstrate that transformation-transactivation domain-associated protein (TRRAP) binding and the recruitment of… 
Highly Cited
2002
Highly Cited
2002
Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes
ABSTRACT The p53 tumor suppressor regulates the cellular response to genetic damage through its function as a sequence-specific… 
Highly Cited
2001
Highly Cited
2001
Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
Molecular therapeutics, targeting the underlying defects leading to cancer initiation and progression, are the “holy grail” of… 
Highly Cited
1998
Highly Cited
1998
The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.
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