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TRRAP gene

Known as: TRANSFORMATION/TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN, Tra1, Transformation/Transcription Domain-Associated Protein Gene 
This gene is involved in DNA repair and regulation of mitosis.
National Institutes of Health

Related topics

Related topics

6 relations
Cell Cycle ControlHomo sapiensTRRAP protein, humanTranscriptional Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer
Purpose This study was designed to assess the protein levels of transformation/transcription domain-associated protein (TRRAP) in… 
2016
2016
The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16
Human cancers frequently arise from increased expression of proto-oncogenes, such as MYC and HER2. Understanding the cellular… 
2014
2014
The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle
Chromosomes are dynamic structures that must be reversibly condensed and unfolded to accommodate mitotic division and chromosome… 
2013
2013
NuA 4 , an essential transcription adaptor / histone H 4 acetyltransferase complex containing Esa 1 p and the ATM-related cofactor Tra 1 p
Laval University Cancer Research Center, Hôtel-Dieu de Québec, Quebec City, Canada G1R 2J6, 1Howard Hughes Medical Institute… 
2012
2012
The skeletal muscle-metabolism axis in prostate-cancer therapy.
n engl j med 367;23 nejm.org december 6, 2012 2257 and 5 of 11 patients with IgM MGUS (45%), as defined by consensus criteria,1… 
2009
2009
Ethylnitrosourea‐induced thymus‐defective mutants identify roles of KIAA1440, TRRAP, and SKIV2L2 in teleost organ development
The thymus is an organ where T lymphocytes develop. Thymus development requires interactions of cells derived from three germ… 
2006
2006
An hGCN5/TRRAP Histone Acetyltransferase Complex Co-activates BRCA1 Transactivation Function through Histone Modification*
It is well established that genetic mutations that impair BRCA1 function predispose women to early onset of breast and ovarian… 
Highly Cited
2003
Highly Cited
2003
Gene expression profiles in human cells submitted to genotoxic stress.
2003
2003
Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells.
Transactivation/transformation-domain associated protein (TRRAP) is a component of several multi-protein HAT complexes implicated… 
Highly Cited
2001
Highly Cited
2001
Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
Molecular therapeutics, targeting the underlying defects leading to cancer initiation and progression, are the “holy grail” of… 
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