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Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
TLDR
The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1), which is modulated by the phosphorylated Ser118 through the Ras-MAPK cascade of the growth factor signaling pathways.
Fgf10 is essential for limb and lung formation
TLDR
It is shown that Fgf10 serves as an essential regulator of lung and limb formation in mice generated with F gf10-deficient mice.
Modulation of microRNA processing by p53
TLDR
This study reveals a previously unrecognized function of p53 in miRNA processing, which may underlie key aspects of cancer biology, and suggests that transcription-independent modulation of miRNA biogenesis is intrinsically embedded in a tumour suppressive program governed by p53.
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
TLDR
It is shown that the agonist-activated AhR/Arnt heterodimer directly associates with oestrogen receptors ER-α and ER-β, which results in the recruitment of unliganded ER and the co-activator p300 to ostrogen-responsive gene promoters, leading to activation of transcription and oestrogensic effects.
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
TLDR
It is reported here that in VDR null mutant mice, no defects in development and growth were observed before weaning, irrespective of reduced expression of vitamin D target genes, which establishes a critical role for VDR in growth, bone formation and female reproduction in the post-weaning stage.
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis.
TLDR
It is demonstrated here that Fgf10, a member of the fibroblast growth factor family (FGFs), plays an essential role in the normal development of the pancreas and should prove useful in devising methods to expand pancreatic progenitor cells.
FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development.
TLDR
Results suggest that FGF10 acts as a major ligand for FGFR2b in mouse multi-organ development, which would indicate a role for FGF12 in wide-range organogenesis.
Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects
TLDR
The results suggest that the expression of the novel duodenal epithelial calcium channels (in particular CaT1) is strongly vitamin D-dependent, and that calcium influx, probably interacting with calbindin-D9K, should be considered as a rate-limiting step in the process of vitamin D -dependent active calcium absorption.
Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo.
TLDR
The results suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor.
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