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Evaluation of chromosomal aberrations, micronuclei, and sister chromatid exchanges in hospital workers chronically exposed to ionizing radiation.
- R. S. Cardoso, S. Takahashi-Hyodo, P. Peitl, T. Ghilardi-Neto, E. Sakamoto-Hojo
- Biology, Medicine
- Teratogenesis, carcinogenesis, and mutagenesis
The increased frequencies of CA and SCE in radiation workers indicate the cumulative effect of low-level chronic exposure to ionizing radiation, and the relevance of conducting cytogenetic analysis in parallel to physical dosimetry in the working place. Expand
Gene Expression Profiles in Human Lymphocytes Irradiated In Vitro with Low Doses of Gamma Rays
Low to moderate radiation doses induced qualitative and/or quantitative differences and similarities in transcript profiles, reflecting the type and extent of DNA lesions, and indicate a potential risk to humans regarding the development of genetic instability and acquired diseases. Expand
Gene expression profiles in radiation workers occupationally exposed to ionizing radiation.
Ionizing radiation (IR) imposes risks to human health and the environment. IR at low doses and low dose rates has the potency to initiate carcinogenesis. Genotoxic environmental agents such as IR… Expand
137Cesium-induced chromosome aberrations analyzed by fluorescence in situ hybridization: eight years follow up of the Goiânia radiation accident victims.
The frequencies of translocations observed years after the radiation exposure were two to three times lower than the initial dicentrics frequencies, the differences being larger at higher doses (>1 Gy), and factors such as the persistence of translocation carrying lymphocytes, translocation levels not proportional to chromosome size, and inter-individual variation reduce the precision. Expand
Cytogenetic Characterization of Two Partamona Species (Hymenoptera, Apinae, Meliponini) by Fluorochrome Staining and Localization of 18S rDNA Clusters by FISH
Supernumerary pericentromeric heterochromatin and the non-homologous portion of a heteromorphic pair behaved in a similar fashion, indicating that may be originated by fission. Expand
MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus.
Type 1 diabetes mellitus (T1DM) results from an autoimmune attack against the insulin-producing pancreatic β-cells, leading to elimination of insulin production. The exact cause of this disorder is… Expand
Evidence for a network transcriptional control of promiscuous gene expression in medullary thymic epithelial cells.
Findings provide evidence that Aire plays a role in association with Gucy2d, which is connected to several PTA genes and establishes a cascade-like transcriptional control of promiscuous gene expression in mTEC cells. Expand
Galanthamine decreases genotoxicity and cell death induced by β-amyloid peptide in SH-SY5Y cell line.
- W. O. Castillo, A. Aristizábal-Pachon, A. P. de Lima Montaldi, E. Sakamoto-Hojo, C. Takahashi
- Biology, Medicine
- 1 December 2016
It is demonstrated that in addition to inhibition of acetylcholinesterase (AChE), galanthamine exerts antigenotoxic properties which may improve the development of new diseases-modifying agents. Expand
Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1.
- F. M. de Oliveira, L. Tone, +7 authors E. Rego
- Biology, Medicine
- Cancer genetics and cytogenetics
- 15 January 2007
Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization studies revealed an abnormal karyotype in all cells examined, but FISH analysis demonstrated absence of translocations in the region of the cyclin D1 gene. Expand
Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients
BackgroundRegardless the regulatory function of microRNAs (miRNA), their differential expression pattern has been used to define miRNA signatures and to disclose disease biomarkers. To address the… Expand