TRPP Cation Channels

Known as: TRPP Cation Channels [Chemical/Ingredient], Cation Channels, TRPP, Polycystins 
A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES.
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
Recent evidence suggests that fibrocystin/polyductin (FPC), polycystin-1 (PC1), and polycystin-2 (PC2) are all localized at the… (More)
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Highly Cited
2006
Highly Cited
2006
A "two-hit" hypothesis predicts a second somatic hit, in addition to the germline mutation, as a prerequisite to cystogenesis and… (More)
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Highly Cited
2005
Highly Cited
2005
Autosomal dominant polycystic kidney disease, a common cause of renal failure, arises from mutations in either the PKD1 or the… (More)
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Highly Cited
2004
Highly Cited
2004
Studies of mechanotransduction mediated by stress-sensitive ion channels generally focus on the site of force application to the… (More)
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Highly Cited
2003
Highly Cited
2003
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize to cilia. Furthermore, cilia are… (More)
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Highly Cited
2002
Highly Cited
2002
Recent evidence has suggested an association between structural and/or functional defects in the primary apical cilium of… (More)
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Highly Cited
2001
Highly Cited
2001
Autosomal dominant polycystic kidney disease (ADPKD) is common and is a major cause of renal failure. Although the genetics of… (More)
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Highly Cited
2001
Highly Cited
2001
Mutations in polycystins-1 and -2 (PC1 and PC2) cause autosomal dominant polycystic kidney disease (ADPKD), which is… (More)
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Highly Cited
2000
Highly Cited
2000
Cystogenesis associated with autosomal dominant polycystic kidney disease (ADPKD) is characterized by perturbations in the… (More)
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Highly Cited
1999
Highly Cited
1999
Polycystic kidney diseases are genetic disorders in which the renal parenchyma is progressively replaced by fluid-filled cysts… (More)
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