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TRPP Cation Channels

Known as: TRPP Cation Channels [Chemical/Ingredient], Cation Channels, TRPP, Polycystins 
A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES.
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
Kidney cysts occur following inactivation of polycystins in otherwise intact cilia or following complete removal of cilia by… Expand
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Highly Cited
2009
Highly Cited
2009
Autosomal-dominant polycystic kidney disease, the most frequent monogenic cause of kidney failure, is induced by mutations in the… Expand
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Highly Cited
2006
Highly Cited
2006
Significant progress in understanding the molecular mechanisms of polycystic kidney disease (PKD) has been made in recent years… Expand
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Highly Cited
2003
Highly Cited
2003
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize to cilia. Furthermore, cilia are… Expand
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Highly Cited
2002
Highly Cited
2002
Recent evidence has suggested an association between structural and/or functional defects in the primary apical cilium of… Expand
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Highly Cited
2002
Highly Cited
2002
We thank Dr J. Lawrence and members of her laboratory for microscope time and assistance, Dr P. Furcinitti for assistance, and… Expand
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Highly Cited
2001
Highly Cited
2001
Autosomal dominant polycystic kidney disease (ADPKD) is common and is a major cause of renal failure. Although the genetics of… Expand
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Highly Cited
2001
Highly Cited
2001
Mutations in polycystins-1 and -2 (PC1 and PC2) cause autosomal dominant polycystic kidney disease (ADPKD), which is… Expand
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Highly Cited
1999
Highly Cited
1999
The stereotyped mating behaviour of the Caenorhabditis elegans male is made up of several substeps: response, backing, turning… Expand
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Highly Cited
1999
Highly Cited
1999
Polycystic kidney diseases are genetic disorders in which the renal parenchyma is progressively replaced by fluid-filled cysts… Expand
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