polycystic kidney disease 1 protein

Known as: pcy protein, Polycystin-1, PKD1 protein 
Polycystin-1 (4303 aa, ~463 kDa) is encoded by the human PKD1 gene. This protein may play a role in protein-protein and protein-carbohydrate… (More)
National Institutes of Health

Papers overview

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Review
2009
Review
2009
A number of inherited disorders result in renal cyst development. The most common form, autosomal dominant polycystic kidney… (More)
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Highly Cited
2006
Highly Cited
2006
Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disorder that frequently leads to renal failure… (More)
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Highly Cited
2006
Highly Cited
2006
Primary cilia are implicated in the pathogenesis of autosomal-dominant polycystic kidney disease (ADPKD), which results from… (More)
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Highly Cited
2003
Highly Cited
2003
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize to cilia. Furthermore, cilia are… (More)
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Highly Cited
2002
Highly Cited
2002
Recent evidence has suggested an association between structural and/or functional defects in the primary apical cilium of… (More)
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Highly Cited
2002
Highly Cited
2002
Defects in the PKD1 and PKD2 genes cause autosomal dominant polycystic kidney disease (PKD) in ~1 in 1000 adults worldwide. These… (More)
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Highly Cited
2002
Highly Cited
2002
Polycystin-1 plays an essential role in renal tubular morphogenesis, and disruption of its function causes cystogenesis in human… (More)
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Highly Cited
2000
Highly Cited
2000
The human kidney is composed of roughly 1.2-million renal tubules that must maintain their tubular structure to function properly… (More)
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Highly Cited
1998
Highly Cited
1998
Analysis of the C-terminal cytosolic domain of human and mouse polycystin-1 has identified a number of conserved protein motifs… (More)
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Highly Cited
1996
Highly Cited
1996
Polycystic kidney disease 1 (PKD1) is the major locus of the common genetic disorder autosomal dominant polycystic kidney disease… (More)
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