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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
GSK126, a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity, decreases global H3K27me3 levels and reactivates silenced PRC2 target genes and markedly inhibits the growth of EzH2 mutant DLBCL xenografts in mice are demonstrated.
Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment
Aflatoxin may play a causative role in 4.6–28.2% of all global HCC cases, and most cases occur in sub-Saharan Africa, Southeast Asia, and China where populations suffer from both high HBV prevalence and largely uncontrolled aflatoxin exposure in food.
25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study.
Low levels of 25(OH)D are associated with higher risk of myocardial infarction in a graded manner, even after controlling for factors known to be associated with coronary artery disease.
Demographic science aids in understanding the spread and fatality rates of COVID-19
The role of age structure in deaths thus far in Italy and South Korea and how the pandemic could unfold in populations with similar population sizes but different age structures are examined, showing a dramatically higher burden of mortality in countries with older versus younger populations.
The C Termini of Arabidopsis Cryptochromes Mediate a Constitutive Light Response
Risk factors for prostate cancer incidence and progression in the health professionals follow‐up study
- E. Giovannucci, Yan Liu, E. Platz, M. Stampfer, W. Willett
- MedicineInternational journal of cancer
- 1 October 2007
Although the proportion of advanced stage cancers was much lower after PSA screening began, risk factors for advanced stage prostate cancers were similar in the pre‐PSA and PSA era.
Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export
- Stephanie S. ‐I Tseng, P. L. Weaver, Yan Liu, M. Hitomi, A. Tartakoff, T. Chang
- BiologyThe EMBO journal
- 1 May 1998
It is shown here that Dbp5p is an ATP‐dependent RNA helicase required for polyadenylated [poly(A)+] RNA export and may play a role in unloading or remodeling messenger RNA particles (mRNPs) upon arrival in the cytoplasm and in coupling mRNP export and translation.
A prospective study of tomato products, lycopene, and prostate cancer risk.
- E. Giovannucci, E. Rimm, Yan Liu, M. Stampfer, W. Willett
- MedicineJournal of the National Cancer Institute
- 6 March 2002
Frequent consumption of tomato products is associated with a lower risk of prostate cancer, and these associations persisted in analyses controlling for fruit and vegetable consumption and for olive oil use and were observed separately in men of Southern European or other Caucasian ancestry.
New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.
Exposure to radiation therapy is the most important risk factor for the development of a new CNS tumor in survivors of childhood cancers and the higher risk of subsequent glioma in children irradiated at a very young age may reflect greater susceptibility of the developing brain to radiation.
Deep Learning: A Generic Approach for Extreme Condition Traffic Forecasting
This work builds a deep neural network based on long short term memory (LSTM) units and applies Deep LSTM to forecast peak-hour traffic and manages to identify unique characteristics of the traffic data.