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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
In eukaryotes, post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the polycomb repressive complex 2Expand
Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment
Background Hepatocellular carcinoma (HCC), or liver cancer, is the third leading cause of cancer deaths worldwide, with prevalence 16–32 times higher in developing countries than in developedExpand
The C Termini of Arabidopsis Cryptochromes Mediate a Constitutive Light Response
Cryptochrome blue light photoreceptors share sequence similarity to photolyases, flavoproteins that mediate light-dependent DNA repair. However, cryptochromes lack photolyase activity and areExpand
25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study.
BACKGROUND Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans. METHODS We assessed prospectively whether plasma 25-hydroxyvitamin DExpand
Risk factors for prostate cancer incidence and progression in the health professionals follow‐up study
Risk factors for prostate cancer could differ for various sub‐groups, such as for “aggressive” and “non‐aggressive” cancers or by grade or stage. Determinants of mortality could differ from those forExpand
Kernel conditional random fields: representation and clique selection
Kernel conditional random fields (KCRFs) are introduced as a framework for discriminative modeling of graph-structured data through the use of graph kernels. Expand
Fast Multivariate Spatio-temporal Analysis via Low Rank Tensor Learning
We propose a unified low rank tensor learning framework for multivariate spatio-temporal analysis, which can conveniently incorporate different properties in spatiotemporal data such as spatial clustering and shared structure among variables. Expand
New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.
BACKGROUND Subsequent primary neoplasms of the central nervous system (CNS) have frequently been described as late events following childhood leukemia and brain tumors. However, the details of theExpand
Genome sequencing of the high oil crop sesame provides insight into oil biosynthesis
BackgroundSesame, Sesamum indicum L., is considered the queen of oilseeds for its high oil content and quality, and is grown widely in tropical and subtropical areas as an important source of oil andExpand
Grouped graphical Granger modeling for gene expression regulatory networks discovery
We consider the problem of discovering gene regulatory networks from time-series microarray data. Expand