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TREX1 gene

Known as: 3-PRIME REPAIR EXONUCLEASE 1, DRN3, three prime repair exonuclease 1 
This gene is involved in DNA repair.
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which… Expand
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Highly Cited
2015
Highly Cited
2015
Aicardi–Goutières syndrome is an inflammatory disease occurring due to mutations in any of TREX1, RNASEH2A, RNASEH2B, RNASEH2C… Expand
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Highly Cited
2013
Highly Cited
2013
The sensing of viral nucleic acids by the innate immune system triggers the production of type I interferons, which activates… Expand
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Highly Cited
2010
Highly Cited
2010
1005 Human immunodeficiency virus (HIV) introduces its single-stranded RNA (ssRNA) genome into a cell in the reverse… Expand
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Highly Cited
2008
Highly Cited
2008
Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of antiviral defense but can cause… Expand
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Highly Cited
2007
Highly Cited
2007
TREX1 acts in concert with the SET complex in granzyme A–mediated apoptosis, and mutations in TREX1 cause Aicardi-Goutières… Expand
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Highly Cited
2007
Highly Cited
2007
Trex1 is the major 3' DNA exonuclease in mammalian cells, and mutations in the human TREX1 gene can cause Aicardi-Goutières… Expand
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Highly Cited
2007
Highly Cited
2007
Autosomal dominant retinal vasculopathy with cerebral leukodystrophy is a microvascular endotheliopathy with middle-age onset. In… Expand
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Highly Cited
2006
Highly Cited
2006
Aicardi-Goutières syndrome (AGS) presents as a severe neurological brain disease and is a genetic mimic of the sequelae of… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT TREX1, originally designated DNase III, was isolated as a major nuclear DNA-specific 3′→5′ exonuclease that is widely… Expand
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