Skip to search formSkip to main contentSkip to account menu

TREX1 gene

Known as: 3-PRIME REPAIR EXONUCLEASE 1, DRN3, three prime repair exonuclease 1 
This gene is involved in DNA repair.
National Institutes of Health

Related topics

Related topics

10 relations
ATRIP geneDNA RepairDNA ReplicationExodeoxyribonuclease III

Narrower (1)

TREX1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
A homozygote TREX1 mutation in two siblings with different phenotypes: Chilblains and cerebral vasculitis.
2017
2017
A Hippo in the Fox(p3) house
The Hippo signaling pathway regulates cellular proliferation and survival during tissue growth and cancer. In CD4+ T cells… 
2014
2014
IFNαR Signaling in Effector but Not Regulatory T Cells Is Required for Immune Dysregulation during Type I IFN–Dependent Inflammatory Disease
Type I IFNs are a family of proinflammatory cytokines that are essential for antiviral immunity but whose overexpression is… 
2014
2014
Genetic variation in Trex1 affects HIV-1 disease progression
Objective:Three prime repair exonuclease 1 (TREX1) plays a pivotal role in HIV-1 infection. In-vitro studies have shown that… 
2014
2014
TLR ligands up‐regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF‐κB‐dependent signaling pathways
Mutations in the Trex1 are associated with a spectrum of type I IFN‐dependent autoimmune diseases. Trex1 plays an essential role… 
2012
2012
Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection
Three prime repair exonuclease 1 (TREX1) degrades excess HIV-1 DNA, thereby preventing recognition by innate immunity receptors… 
2012
2012
Inhibition of neuroblastoma cell growth by TREX1-mutated human lymphocytes.
T lymphocytes play a major role in counteracting cancer occurrence and development. Immune therapies against cancer are focused… 
2010
2010
Host DNase TREX1 hides HIV from DNA sensors
Human immunodeficiency virus type 1 (HIV-1) seems to avoid detection by nucleic acid sensors. This is probably due to the host… 
2010
2010
The TREX1 3' exonuclease and autoimmune disease: Structural and biochemical analysis of disease mutants involved in autoimmune dysfunction
The homodimeric TREX1 protein is a member of the DnaQ family of exonucleases and catalyzes the major 3′ exonuclease activity… 
2008
2008
TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus
Three-prime repair exonucleases 1 and 2 (TREX1 and TREX2) play a role in the metabolism and clearance of DNA. The objective of… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)