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TREX1 gene

Known as: 3-PRIME REPAIR EXONUCLEASE 1, DRN3, three prime repair exonuclease 1 
This gene is involved in DNA repair.
National Institutes of Health

Related topics

Related topics

10 relations
ATRIP geneDNA RepairDNA ReplicationExodeoxyribonuclease III

Narrower (1)

TREX1 wt Allele

Papers overview

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2017
2017
A Hippo in the Fox(p3) house
The Hippo signaling pathway regulates cellular proliferation and survival during tissue growth and cancer. In CD4+ T cells… 
2014
2014
IFNαR Signaling in Effector but Not Regulatory T Cells Is Required for Immune Dysregulation during Type I IFN–Dependent Inflammatory Disease
Type I IFNs are a family of proinflammatory cytokines that are essential for antiviral immunity but whose overexpression is… 
2012
2012
Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection
Three prime repair exonuclease 1 (TREX1) degrades excess HIV-1 DNA, thereby preventing recognition by innate immunity receptors… 
2012
2012
Inhibition of neuroblastoma cell growth by TREX1-mutated human lymphocytes.
T lymphocytes play a major role in counteracting cancer occurrence and development. Immune therapies against cancer are focused… 
2010
2010
Host DNase TREX1 hides HIV from DNA sensors
Human immunodeficiency virus type 1 (HIV-1) seems to avoid detection by nucleic acid sensors. This is probably due to the host… 
2010
2010
The TREX1 3' exonuclease and autoimmune disease: Structural and biochemical analysis of disease mutants involved in autoimmune dysfunction
The homodimeric TREX1 protein is a member of the DnaQ family of exonucleases and catalyzes the major 3′ exonuclease activity… 
2010
2010
Investigation of the interaction of repair DNA polymerase β and autonomous 3′ → 5′-exonucleases TREX1 and TREX2
The possibility of interaction of recombinant proteins of human repair DNA polymerase β with proofreading 3′ → 5′-exonucleases… 
2010
2010
Abstracts of the 9th International Congress on SLE. June 24-27 2010. Vancouver, Canada.
Objectives: We tested the hypothesis that lupus disease is caused by, or contributed to, so-called endogenous retroelements… 
2010
2010
TREX1 mutations are not associated with sporadic inclusion body myositis
Background:  Sporadic inclusion body myositis (sIBM) is the most frequent acquired myopathy above the age of fifty. The exact… 
2008
2008
TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus
Three-prime repair exonucleases 1 and 2 (TREX1 and TREX2) play a role in the metabolism and clearance of DNA. The objective of… 
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