TREX1 gene

Known as: 3-PRIME REPAIR EXONUCLEASE 1, DRN3, three prime repair exonuclease 1 
This gene is involved in DNA repair.
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which… (More)
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Highly Cited
2008
Highly Cited
2008
Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of antiviral defense but can cause… (More)
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Highly Cited
2007
Highly Cited
2007
Trex1 is the major 3' DNA exonuclease in mammalian cells, and mutations in the human TREX1 gene can cause Aicardi-Goutières… (More)
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Highly Cited
2007
Highly Cited
2007
TREX1 acts in concert with the SET complex in granzyme A–mediated apoptosis, and mutations in TREX1 cause Aicardi-Goutières… (More)
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Highly Cited
2007
Highly Cited
2007
TREX1 constitutes the major 3'-->5' DNA exonuclease activity measured in mammalian cells. Recently, biallelic mutations in TREX1… (More)
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Highly Cited
2007
Highly Cited
2007
Autosomal dominant retinal vasculopathy with cerebral leukodystrophy is a microvascular endotheliopathy with middle-age onset. In… (More)
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Highly Cited
2006
Highly Cited
2006
Aicardi-Goutières syndrome (AGS) presents as a severe neurological brain disease and is a genetic mimic of the sequelae of… (More)
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Highly Cited
2006
Highly Cited
2006
Granzyme A (GzmA) activates a caspase-independent cell death pathway with morphological features of apoptosis. Single-stranded… (More)
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Highly Cited
2004
Highly Cited
2004
TREX1, originally designated DNase III, was isolated as a major nuclear DNA-specific 3'-->5' exonuclease that is widely… (More)
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Highly Cited
1999
Highly Cited
1999
The 3'-->5' exonucleases catalyze the excision of nucleoside monophosphates from the 3' termini of DNA. We have identified the… (More)
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