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The role of oxidative stress in glaucoma.
DNA damage is related to a variety of degenerative diseases such as cancer, atherosclerosis and neurodegenerative diseases, depending on the tissue affected. Increasing evidence indicates thatExpand
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Glaucomatous outflow pathway and oxidative stress.
Oxidative free radicals and reactive oxygen species (ROS) are able to affect the cellularity of the human trabecular meshwork (HTM). These findings suggest that intraocular pressure increase, whichExpand
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Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients.
BACKGROUND Little is known about the molecular mechanisms responsible for the development of glaucoma, the leading cause of irreversible blindness worldwide. Some investigators have hypothesized thatExpand
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Mitochondrial damage in the trabecular meshwork of patients with glaucoma.
OBJECTIVES To analyze the frequency of mitochondrial DNA (mtDNA) damage in patients with primary open-angle glaucoma. Oxidative damage plays a major role in glaucoma pathogenesis. Since noExpand
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Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke
Although microRNAs have been investigated extensively in cancer research, little is known regarding their response to noxious agents in apparently healthy tissues. We analyzed the expression of 484Expand
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Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma.
OBJECTIVE To evaluate the intensity of oxidative molecular damage and its clinical correlations: visual field damage, intraocular pressure, age, and disease duration. METHODS DNA was extracted fromExpand
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Oxidative stress and glaucoma: injury in the anterior segment of the eye.
The perturbation of the pro-oxidant/antioxidant balance can lead to increased oxidative damage, especially when the first line of antioxidant defense weakens with age. Chronic changes in theExpand
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Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points.
Although smoking cessation is the primary goal for the control of cancer and other smoking-related diseases, chemoprevention provides a complementary approach applicable to high risk individuals suchExpand
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The Outflow Pathway: A Tissue With Morphological and Functional Unity
The trabecular meshwork (TM) plays an important role in high‐tension glaucomas. Indeed, the TM is a true organ, through which the aqueous humor flows from the anterior chamber to Schlemm's canalExpand
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Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light
MicroRNAs provide a formidable tool not only in cancer research but also to investigate physiological mechanisms and to assess the effect of environmental exposures in healthy tissues. Collectively,Expand
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