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TP53 gene

Known as: TUMOR PROTEIN p53, Tumor Protein P53 (Li-Fraumeni Syndrome) Gene, Gene, TP53 
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
National Institutes of Health

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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Structural biology of the tumor suppressor p53.
The tumor suppressor protein p53 induces or represses the expression of a variety of target genes involved in cell cycle control… 
Highly Cited
2005
Highly Cited
2005
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro… 
Highly Cited
2002
Highly Cited
2002
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
The tumour-suppressor gene p53 is frequently mutated in human cancers and is important in the cellular response to DNA damage… 
Review
1999
Review
1999
Regulation of the p53 Tumor Suppressor Protein*
Mutations in the p53 tumor suppressor gene occur in about 50% of all human tumors, making it the most frequent target for genetic… 
Review
1997
Review
1997
Cadmium, gene regulation, and cellular signalling in mammalian cells.
Effects of the carcinogenic metal cadmium on the regulation of mammalian gene expression are reviewed and discussed in the light… 
Highly Cited
1994
Highly Cited
1994
Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death
Highly Cited
1993
Highly Cited
1993
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
THE tumour-suppressor gene p53 is inactivated in most human malignancies1 either by missense mutations1 or by binding to… 
Highly Cited
1993
Highly Cited
1993
Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.
Approximately half of hepatocellular carcinoma (HCC) from regions in the world with high contamination of food with the mycotoxin… 
Highly Cited
1991
Highly Cited
1991
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
Human cervical carcinoma cell lines that were either positive or negative for human papillomavirus (HPV) DNA sequences were… 
Highly Cited
1990
Highly Cited
1990
Genetic mechanisms of tumor suppression by the human p53 gene
Mutations of the gene encoding p53, a 53-kilodalton cellular protein, are found frequently in human tumor cells, suggesting a… 
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