TP53 gene

Known as: TUMOR PROTEIN p53, Tumor Protein P53 (Li-Fraumeni Syndrome) Gene, Gene, TP53 
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53 gene alters its response pathway… (More)
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Highly Cited
2011
Highly Cited
2011
The tumor suppressor p53, encoded by the TP53 gene, is recognized as the guardian of the human genome because it regulates many… (More)
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Highly Cited
2003
Highly Cited
2003
Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers. The… (More)
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Highly Cited
2002
Highly Cited
2002
We have recently shown that loss of heterozygosity of specific markers, including those at 10q23, 17p13–p15 and 16q24, can occur… (More)
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Highly Cited
1999
Highly Cited
1999
The hCHK2 gene encodes the human homolog of the yeast Cds1 and Rad53 G2 checkpoint kinases, whose activation in response to DNA… (More)
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Review
1997
Review
1997
These results clearly point out that p53 uses a hyThe p53 gene and its protein product have become the drophobic interface in its… (More)
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Highly Cited
1997
Highly Cited
1997
We describe a gene encoding p73, a protein that shares considerable homology with the tumor suppressor p53. p73 maps to 1p36, a… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Alterations of the TP53 tumor suppressor gene appear to be implicated in the tumorigenesis and progression of several… (More)
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Highly Cited
1994
Highly Cited
1994
Recombinant adenovirus-mediated transfer of the wild-type p53 gene into monolayer cultures or multicellular tumor spheroids of… (More)
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Highly Cited
1993
Highly Cited
1993
THE tumour-suppressor gene p53 is inactivated in most human malignancies1 either by missense mutations1 or by binding to… (More)
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