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Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population.
It is suggested that the CYP1A1 polymorphism and its combination with GSTM1 may be associated with PCa susceptibility in the Japanese population. Expand
Impact of genetic polymorphisms of 17‐hydroxylase cytochrome P‐450 (CYP17) and steroid 5α‐reductase type II (SRD5A2) genes on prostate‐cancer risk among the Japanese population
A case‐control study of 105 prostate‐cancer patients and 210 controls with benign prostatic hyperplasia is designed, suggesting a significant association between the CYP17 polymorphism and prostate‐ cancer risk among the Japanese. Expand
DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells
It is demonstrated that 8-nitroguanine was strongly formed via inducible nitric oxide synthase (iNOS) expression at these cancer sites of patients, and considered that oxidative and nitrative DNA damage in stem cells may play a key role in inflammation-related carcinogenesis. Expand
Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate.
It is speculated that reduction of KBrO3 by SH compounds in renal proximal tubular cells yields bromine oxides andbromine radicals, which are the reactive species that cause guanine oxidation, leading to renal carcinogenesis of K BrO3. Expand
Mechanism of DNA damage induced by bromate differs from general types of oxidative stress.
A representative reactive oxygen species (ROS), hydroxyl radical (*OH), is a highly reactive species and induces DNA backbone breakage. *OH also oxidizes every DNA base. The interaction of *OH withExpand
Oxidative DNA Damage by Vitamin A and Its Derivative via Superoxide Generation*
It is reported here that vitamin A (retinol) and its derivative (retinal) caused cellular DNA cleavage detected by pulsed field gel electrophoresis, suggesting the involvement of H2O2 in cellular DNA damage. Expand
Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer
Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating evidence indicates thatExpand
The role of metals in site-specific DNA damage with reference to carcinogenesis.
Findings suggest that metal-mediated oxidative DNA damage plays important roles in chemical carcinogenesis. Expand
Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase.
More frequent O.viverrini infection can induce the expression of iNOS not only in inflammatory cells but also in the epithelium of bile ducts and subsequently cause nitrosative and oxidative damage to nucleic acids, which may participate in the initiation and/or promotion steps of cholangiocarcinoma development. Expand
Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer
Interestingly, the nuclear localization of COX-2, which was reported to function as a transcription factor, was significantly associated with the upregulation of Oct3/4 and CD44v6 in bladder cancer tissues with and without S. haematobium infection, respectively. Expand