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Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.
unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus. Expand
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.
- E. Cesarman, Y. Chang, P. Moore, J. Said, D. Knowles
- The New England journal of medicine
- 4 May 1995
A high degree of conservation of KSHV sequences in Kaposi's sarcoma and in the eight lymphomas suggests the presence of the same agent in both lesions, suggesting that a novel herpesvirus has a pathogenic role in AIDS-related body-cavity-based lymphomas. Expand
Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus.
It is recommended that these malignant lymphomas be designated primary effusion lymphomas (PEL), rather than body cavity-based lymphomas, since this term describes them more accurately and avoids their confusion with other malignant cancerous lymphomas that occur in the body cavities. Expand
Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation
- L. Arvanitakis, E. Geras-Raaka, A. Varma, M. Gershengorn, E. Cesarman
- Biology, Medicine
- 23 January 1997
It is shown that the KSHV G-protein-coupled receptor is a bona fide signalling receptor which has constitutive (agonist-independent) activity in the phosphoinositide–inositoltrisphosphate–protein kinase C pathway, making it a candidate viral oncogene. Expand
Kaposi's sarcoma and its associated herpesvirus
The epidemiology of KS and KSHV is described, and the insights into the remarkable mechanisms through which K SHV can induce KS that have been gained in the past 16 years are described. Expand
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator
It is concluded that the KSHV G-protein-coupled receptor is a viral oncogene that can exploit cell signalling pathways to induce transformation and angiogenesis in K SHV-mediated oncogenesis. Expand
In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA…
- E. Cesarman, P. Moore, P. Rao, G. Inghirami, D. Knowles, Y. Chang
- Biology, Medicine
- 1 October 1995
It is demonstrated that the KSHV sequences represent a portion of a much larger DNA molecule that is located predominantly in the nucleus of the infected cells, and that their presence in the cells as large nuclear episomes supports previous sequence homology data suggesting that K SHV belongs to the herpesvirus family. Expand
Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae
The agent is defined as a new human herpesvirus provisionally assigned the descriptive name KS-associated herpesv virus; its formal designation is likely to be human herpes virus 8.0, the first member of this genus known to infect humans. Expand
HIV-associated lymphomas and gamma-herpesviruses.
The current knowledge about HIV-associated lymphomas can be summarized in the following key points: lymphomas specifically occurring in patients with HIV infection are closely linked to other viral diseases; AIDS lymphomas fall in a spectrum of B-cell differentiation where those associated with EBV or KSHV commonly exhibit plasmablastic differentiation. Expand
Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr…
The BC-3 cell line represents an invaluable tool as a source of KSHV, for both the evaluation of the pathogenic potential of this virus and the mechanistic characterization of its role in the development of Kaposi's sarcoma and malignant lymphoma. Expand