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TORC2 complex location

Known as: TOR complex location 2, TORC2, TORC 2 complex location 
A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex… 
National Institutes of Health

Related topics

Related topics

1 relation
CRTC2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice
Background Rictor is an essential component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), a conserved serine… 
Review
2017
Review
2017
Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans
Neurodegenerative diseases (NGDs) such as Alzheimer’s and Parkinson’s are debilitating and largely untreatable conditions… 
2016
2016
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
The mechanistic target of rapamycin (mTOR) is a rational target for cancer treatment. While the mTORC1-selective rapalogs have… 
2015
2015
Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells
Cancer metabolism has greatly interested researchers. Mammalian target of rapamycin (mTOR) is dysregulated in a variety of… 
Review
2011
Review
2011
Benefits of mTOR kinase targeting in oncology: pre-clinical evidence with AZD8055.
AZD8055 is a small-molecule inhibitor of mTOR (mammalian target of rapamycin) kinase activity. The present review highlights… 
2011
2011
Stress Induces Parallel Changes in Corticotrophin‐Releasing Hormone (CRH) Transcription and Nuclear Translocation of Transducer of Regulated cAMP Response Element‐Binding Activity 2 in Hypothalamic…
Recent studies in vitro have shown that the cAMP response element‐binding (CREB) co‐activator, transducer of regulated CREB… 
Review
2010
Review
2010
Novel inhibitors of mTORC1 and mTORC2.
The PI3K/Akt/mTOR pathway is frequently activated in human cancers, and mTOR is a clinically validated target for therapeutic… 
2009
2009
Obestatin stimulates Akt signalling in gastric cancer cells through beta-arrestin-mediated epidermal growth factor receptor transactivation.
Obestatin was identified as a gut peptide encoded by the ghrelin gene that interacts with the G protein-coupled receptor, GPR39… 
2008
2008
CD40-Induced Signaling in Human Endothelial Cells Results in mTORC2- and Akt-Dependent Expression of Vascular Endothelial Growth Factor In Vitro and In Vivo1
We have examined CD40-dependent signals in endothelial cells (EC) mediating the expression of vascular endothelial growth factor… 
Highly Cited
2007
Highly Cited
2007
Rapamycin regulates the phosphorylation of rictor.
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