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Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2.
Ascorbate (vitamin C) is a vital antioxidant molecule in the brain. However, it also has a number of other important functions, participating as a cofactor in several enzyme reactions, includingExpand
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How does ascorbic acid prevent endothelial dysfunction?
  • J. M. May
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1 May 2000
Human coronary and peripheral arteries show endothelial dysfunction in a variety of conditions, including atherosclerosis, hypercholesterolemia, smoking, and hypertension. This dysfunction manifestsExpand
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Is ascorbic acid an antioxidant for the plasma membrane?
  • J. M. May
  • Chemistry, Medicine
  • FASEB journal : official publication of the…
  • 1 June 1999
Ascorbic acid, or vitamin C, is a primary antioxidant in plasma and within cells, but it can also interact with the plasma membrane by donating electrons to the α‐tocopheroxyl radical and aExpand
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Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity
Neurons maintain relatively high intracellular concentrations of ascorbic acid, which is achieved primarily by the activity of the sodium‐dependent vitamin C transporter SVCT2. In this work, weExpand
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The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C
  • J. M. May
  • Biology, Medicine
  • British journal of pharmacology
  • 1 December 2011
The ascorbate transporters SVCT1 and SVCT2 are crucial for maintaining intracellular ascorbate concentrations in most cell types. Although the two transporter isoforms are highly homologous, theyExpand
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Erythrocyte ascorbate recycling: antioxidant effects in blood.
Ascorbic acid is an important antioxidant in human plasma, but requires efficient recycling from its oxidized forms to avoid irreversible loss. Human erythrocytes prevented oxidation of ascorbate inExpand
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Ascorbate recycling in human erythrocytes: role of GSH in reducing dehydroascorbate.
Human erythrocytes regenerate ascorbate from its oxidized product, dehydroascorbate. The extent to which such ascorbate recycling occurs by a GSH-dependent mechanism was investigated. In the presenceExpand
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Reduction of the Ascorbyl Free Radical to Ascorbate by Thioredoxin Reductase*
Recycling of ascorbic acid from its oxidized forms is required to maintain intracellular stores of the vitamin in most cells. Since the ubiquitous selenoenzyme thioredoxin reductase can recycleExpand
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Mitochondrial uptake and recycling of ascorbic acid.
Mitochondria generate reactive oxygen species as by-products of oxidative metabolism. Since ascorbic acid can scavenge such destructive species, we studied the ability of mitochondria from rat liverExpand
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Coordinate regulation of L-arginine uptake and nitric oxide synthase activity in cultured endothelial cells.
Despite intracellular L-arginine concentrations that should saturate endothelial nitric oxide synthase (eNOS), nitric oxide production depends on extracellular L-arginine. We addressed this 'arginineExpand
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