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TOR complex 1

Known as: TORC1 complex location, dTORC1, rapamycin and nutrient-sensitive TOR complex 
A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex… 
National Institutes of Health

Related topics

Related topics

2 relations
CREB-Regulated Transcription Coactivator 1CRTC1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction
TORC1, a central regulator of cell survival, growth, and metabolism, is activated in a variety of cancers. Loss of the tumor… 
2017
2017
TORC1‐mediated sensing of chaperone activity alters glucose metabolism and extends lifespan
Protein quality control mechanisms, required for normal cellular functioning, encompass multiple functions related to protein… 
2015
2015
The yeast chromatin remodeler Rsc1-RSC complex is required for transcriptional activation of autophagy-related genes and inhibition of the TORC1 pathway in response to nitrogen starvation.
2014
2014
Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells
The target of rapamycin (TOR) is an important signaling pathway on a hierarchical network of interacting pathways regulating… 
2014
2014
Endolysosomal Membrane Trafficking Complexes Drive Nutrient-Dependent TORC1 Signaling to Control Cell Growth in Saccharomyces cerevisiae
The rapamycin-sensitive and endomembrane-associated TORC1 pathway controls cell growth in response to nutrients in eukaryotes… 
2014
2014
Hyperactivated Wnt Signaling Induces Synthetic Lethal Interaction with Rb Inactivation by Elevating TORC1 Activities
Inactivation of the Rb tumor suppressor can lead to increased cell proliferation or cell death depending on specific cellular… 
2014
2014
Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor
In human cells TORC1 mTOR (target of rapamycin) protein kinase complex renders heat shock transcription factor 1 (Hsf1) competent… 
Review
2012
Review
2012
The oxysterol-binding protein superfamily: new concepts and old proteins.
The Kes1 OSBP (oxysterol-binding protein) is a key regulator of membrane trafficking through the TGN (trans-Golgi network) and… 
Highly Cited
2007
Highly Cited
2007
Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae.
The TOR kinases are regulators of growth in eukaryotic cells that assemble into two distinct protein complexes, TORC1 and TORC2… 
2006
2006
The Association of Tap42-Phosphatase Complexes with TORC1 — Another Level of Regulation in Tor Signaling
In the budding yeast Saccharomyces cerevisiae, rapamycin has been known to induce a rapid dephosphorylation of many downstream… 
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