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Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
Nonallelic noncomplementation between FPR1, TOR1, and TOR2 alleles suggests that the products of these genes may interact as subunits of a protein complex that may mediate nuclear entry of signals required for progression through the cell cycle.
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans
It is concluded that GSNO reductase is evolutionarily conserved from bacteria to humans, is critical for SNO homeostasis, and protects against nitrosative stress.
The Paleozoic Origin of Enzymatic Lignin Decomposition Reconstructed from 31 Fungal Genomes
Comparative analyses of 31 fungal genomes suggest that lignin-degrading peroxidases expanded in the lineage leading to the ancestor of the Agaricomycetes, which is reconstructed as a white rot species, and then contracted in parallel lineages leading to brown rot and mycorrhizal species.
Signal Transduction Cascades Regulating Fungal Development and Virulence
- K. Lengeler, R. Davidson, J. Heitman
- BiologyMicrobiology and Molecular Biology Reviews
- 1 December 2000
This analysis illustrates both how the model yeast S. cerevisiae can serve as a paradigm for signaling in other organisms and also how studies in other fungi provide insights into conserved signaling pathways that operate in many divergent organisms.
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence in Candida albicans species.
Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak
It is demonstrated how cryptic same-sex reproduction can enable expansion of a human pathogen to a new geographical niche and contribute to the ongoing production of infectious spores.
Cyclic AMP-Dependent Protein Kinase Regulates Pseudohyphal Differentiation in Saccharomyces cerevisiae
The cAMP-dependent protein kinase plays an intimate positive and negative role in regulating filamentous growth, and these findings may provide insight into the roles of PKA in mating, morphogenesis, and virulence in other yeasts and pathogenic fungi.
The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae
It is proposed that MEP2, a high affinity ammonium permease, is an ammonium sensor, generating a signal to regulate filamentous growth in response to ammonium starvation.
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
- J. Heitman
- 1 August 2000
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many different…