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TOP3B gene

Known as: TOP3B, TOPOISOMERASE III-BETA, TOPOISOMERASE, DNA, III, BETA 
This gene is involved in DNA recombination, cellular aging and the maintenance of genome integrity.
National Institutes of Health

Related topics

Related topics

5 relations
Cell AgingDNA stabilityRecombination, GeneticTOP3B protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses
Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on… 
Highly Cited
2018
Highly Cited
2018
Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization
Abstract DNA topoisomerase 3B (TOP3B) is unique among all mammalian topoisomerases for its dual activities that resolve both DNA… 
2018
2018
TOP3B: A Novel Candidate Gene in Juvenile Myoclonic Epilepsy?
Juvenile myoclonic epilepsy (JME) is characterized by seizures, severe cognitive abnormalities, and behavior impairments. These… 
Highly Cited
2017
Highly Cited
2017
Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan–Meier plotter
DNA topoisomerases are essential to modulate DNA topology during various cellular genetic processes. The expression and distinct… 
Review
2016
Review
2016
Deletion of TOP3B Is Associated with Cognitive Impairment and Facial Dysmorphism
Deletions of different regions of chromosome 22q11 have been extensively characterized in the literature, with a recent review… 
2014
2014
Microduplications in 22q11.2 and 8q22.1 associated with mild mental retardation and generalized overgrowth.
2013
2013
The Top3β way to untangle RNA
With evidence from model organisms and human population genetic analysis, two studies in this issue report discoveries that… 
Highly Cited
2009
Highly Cited
2009
Non-small cell lung cancer exhibits transcript overexpression of genes associated with homologous recombination and DNA replication pathways.
Genes involved in DNA repair and replication have been recently investigated as predictive markers of response to chemotherapy in… 
2005
2005
Chromosome 22 tiling‐path array–CGH analysis identifies germ‐line‐ and tumor‐specific aberrations in patients with glioblastoma multiforme
Gliomas are common and frequently malignant tumors of the central nervous system. Recurrent allelic losses of chromosome 22 have… 
1992
1992
Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells.
Efficacy of camptothecins (CPTs) such as irinotecan has been recognized in chemotherapy of cancers including melanoma. However… 
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