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Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
TLDR
Analysis of 6,000 CpG islands showed that only a small set of promoters was methylated differentially, suggesting that aberrant methylation of CpGs island promoters in malignancy might be less frequent than previously hypothesized. Expand
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
TLDR
Deletes chromosome 5q and identifies Toll–interleukin-1 receptor domain–containing adaptor protein (TIRAP) and tumor necrosis factor receptor–associated factor-6 (TRAF6) as respective targets of these miRNAs. Expand
A comprehensive analysis of common copy-number variations in the human genome.
TLDR
An in-depth survey of CNVs across the human genome provides a valuable baseline for studies involving human genetics and raises the possibility of the contribution of microRNAs to phenotypic diversity in humans. Expand
A tiling resolution DNA microarray with complete coverage of the human genome
TLDR
The constructed tiling resolution array allows comprehensive assessment of genomic integrity and thereby the identification of new genes associated with disease and shows the need to move beyond conventional marker-based genome comparison approaches, that rely on inference of continuity between interval markers. Expand
Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.
Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its most common histological subtype. Clinical and molecular evidence indicates that lung adenocarcinoma is aExpand
The functional role of long non-coding RNA in human carcinomas
TLDR
The emerging functional role of lncRNAs in human cancer is highlighted and molecular mechanisms by which these RNA species function are described, providing insight into the functional roles they may play in tumorigenesis. Expand
Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.
  • M. Rosin, X. Cheng, +8 authors L. Zhang
  • Medicine, Biology
  • Clinical cancer research : an official journal of…
  • 1 February 2000
TLDR
Analysis of LOH at 3p and 9p could serve as an initial screening for cancer risk of early premalignancies and follow-up investigation for additional losses would be essential for predicting cancer progression. Expand
PIK3CA mutations and copy number gains in human lung cancers.
TLDR
PIK3CA mutations or gains are present in a subset of lung cancers and are of functional importance and associated with increased phosphatidylinositol 3-kinase activity and phosphorylated Akt expression. Expand
Transformation methods for halophilic archaebacteria.
TLDR
This method has been applied to phage DNA transfection, plasmid DNA transformation, and transformation with linear fragments of high molecular weight genomic DNA and should find application in molecular cloning, genetic fine mapping, and strain construction. Expand
Shuttle vectors for the archaebacterium Halobacterium volcanii.
  • W. Lam, W. Doolittle
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 July 1989
TLDR
A genetic determinant for resistance to the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor mevinolin was isolated by "shotgun cloning" into a derivative of the endogenous H. volcanii plasmid pHV2, to form pWL2, which transforms sensitive H. volunteeredi to mevinol resistance at high frequency. Expand
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