TOK-001

Known as: VN/124, VN/124-1 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2016
02420082016

Papers overview

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2015
2015
In our effort to discover potent and specific inhibitors of 17α-hydroxylase/17,20-lyase (CYP17), the key enzyme which catalyzes… (More)
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2015
2015
Cytochrome P450 17A1 (CYP17A1) is associated in the steroid hormone biosynthesis in human. As cell proliferation of prostate… (More)
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Review
2014
Review
2014
Prostate cancer is an internationally important health problem of the man, particularly in developed countries. Currently the… (More)
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2012
2012
Cytochrome P450 17A1 (also known as CYP17A1 and cytochrome P450c17) catalyses the biosynthesis of androgens in humans. As… (More)
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2012
2012
TOK-001 and abiraterone are potent 17-heteroarylsteroid (17-HAS) inhibitors of Cyp17, one of the rate-limiting enzymes in the… (More)
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Review
2010
Review
2010
The beneficial effect of androgen ablation has been well established in prostate cancer therapy. Despite the initial response… (More)
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2008
2008
We previously reported that our novel compound 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene (VN/124-1) is a potent… (More)
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2008
2008
This study was carried out to determine the mechanisms associated with loss of androgen dependency and disease progression in… (More)
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2008
2008
Inhibitors of the enzyme 17alpha-hydroxylase/17,20 lyase are a new class of anti-prostate cancer agents currently undergoing… (More)
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2008
2008
We previously reported that our novel compound 3Bhydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene (VN/124-1) is a potent 17A… (More)
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